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    ste4 MAPK cascade adaptor protein Ste4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541677, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ste4
    Official Full Name
    MAPK cascade adaptor protein Ste4
    Primary source
    PomBase:SPAC1565.04c
    Locus tag
    SPOM_SPAC1565.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ste4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1295316..1296543, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit Rcf2 Neighboring gene Rho-type GTPase-activating protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene protein Utp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase Spg1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers. Ramachander R, et al. J Mol Biol, 2004 Oct 1. PMID 15364564
    2. Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4. Ramachander R, et al. J Biol Chem, 2002 Oct 18. PMID 12171939
    3. Multiple regulatory domains on the Byr2 protein kinase. Tu H, et al. Mol Cell Biol, 1997 Oct. PMID 9315645, Free PMC Article
    4. Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Barr MM, et al. Mol Cell Biol, 1996 Oct. PMID 8816472, Free PMC Article
    5. The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. Fontebasso Y, et al. DNA Repair (Amst), 2013 Dec. PMID 24192486, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    MAPK cascade adaptor protein Ste4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1295316..1296543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018713.3 → NP_593283.1  MAPK cascade adaptor protein Ste4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593283.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36622
      Conserved Domains (4) summary
      smart00454
      Location:8 → 70
      SAM; Sterile alpha motif
      smart00314
      Location:177 → 263
      RA; Ras association (RalGDS/AF-6) domain
      pfam07647
      Location:8 → 70
      SAM_2; SAM domain (Sterile alpha motif)
      cl23765
      Location:81 → 143
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein
    Heading Accession and Version

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