FMS1 polyamine oxidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FMS1
Official Full Name: polyamine oxidase
Primary source: SGD:S000004622
Locus tag: YMR020W
See related: AllianceGenome:SGD:S000004622; FungiDB:YMR020W; VEuPathDB:YMR020W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables polyamine oxidase activity. Involved in pantothenate biosynthetic process and spermine catabolic process. Located in cytoplasm. Orthologous to several human genes including KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See FMS1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (315377..316903)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results are consistent with the role of Asn195 and Asp94 being to properly position the polyamine substrate for oxidation.
Title: Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.
X ray structure; Fms1 consists of an FAD-binding domain, with Rossmann fold topology, and a substrate-binding domain
Title: Crystal structures of Fms1 and its complex with spermine reveal substrate specificity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity	IEA Inferred from Electronic Annotation more info
enables N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables polyamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables polyamine oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables spermine oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

General protein information

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Preferred Names: polyamine oxidase

NP_013733.1

EC 1.5.3.17

Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

315377..316903

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182516.1 → NP_013733.1 TPA: polyamine oxidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013733.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZJ4, P50264

UniProtKB/TrEMBL

A6ZM82, B3LLS1, G2WK71, N1P5C2

Conserved Domains (1) summary

pfam01593
Location:18 → 503

Amino_oxidase; Flavin containing amine oxidoreductase