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    BSD2 Bsd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852593, updated on 28-Oct-2024

    Summary

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    Official Symbol
    BSD2
    Official Full Name
    Bsd2p
    Primary source
    SGD:S000000494
    Locus tag
    YBR290W
    See related
    AllianceGenome:SGD:S000000494; FungiDB:YBR290W; VEuPathDB:YBR290W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in metal ion transport; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum and fungal-type vacuole membrane. Orthologous to human NDFIP1 (Nedd4 family interacting protein 1) and NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See BSD2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (782591..783556)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Apm3p Neighboring gene Snf5p Neighboring gene Ctp1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel role for Bsd2 in the resistance of yeast to adriamycin. Takahashi T, et al. J Cell Physiol, 2005 Jan. PMID 15389553
    2. The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene. Liu XF, et al. Mol Cell Biol, 1994 Nov. PMID 7935419, Free PMC Article
    3. Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene. Liu XF, et al. J Biol Chem, 1999 Feb 19. PMID 9988727
    4. Noise reduction in genome-wide perturbation screens using linear mixed-effect models. Yu D, et al. Bioinformatics, 2011 Aug 15. PMID 21685046, Free PMC Article
    5. The yeast BSD2-1 mutation influences both the requirement for phosphatidylinositol transfer protein function and derepression of phospholipid biosynthetic gene expression in yeast. Kagiwada S, et al. Genetics, 1996 Jun. PMID 8725219, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the resistance to adriamycin acquired by overexpression of BSD2 might be partially explained by down-regulation of Smf2
      Title: A novel role for Bsd2 in the resistance of yeast to adriamycin.
    2. Bsd2 provides an alternative ubiquitination mechanism for Cps1, Phm5 and other proteins
      Title: Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metal ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bsd2p
    NP_009849.1
    • Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      782591..783556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178638.1 → NP_009849.1  TPA: Bsd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQT5, P38356
      UniProtKB/TrEMBL
      A6ZLM8, B3LMM3, B5VEN4, C7GMU2, D3UF37, G2W9U3, N1P8X2
      Conserved Domains (1) summary
      pfam10176
      Location:106 → 319
      DUF2370; Protein of unknown function (DUF2370)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38356.1

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