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    mis12 MIS12/MIND complex Mis12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540494, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mis12
    Official Full Name
    MIS12/MIND complex Mis12
    Primary source
    PomBase:SPBC409.04c
    Locus tag
    SPOM_SPBC409.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mis12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1137753..1139618, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene aromatic ring-opening dioxygenase Neighboring gene ncRNA Neighboring gene putative folylpolyglutamate synthase Neighboring gene translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor Neighboring gene ncRNA Neighboring gene NifU-like protein nfu1 Neighboring gene ncRNA Neighboring gene protein Swi5 Neighboring gene ncRNA Neighboring gene SCF ubiquitin ligase complex subunit Skp1 Neighboring gene ubiquitin hydrolase Uch2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase. Nakaseko Y, et al. Curr Biol, 2001 Apr 17. PMID 11369198
    2. Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe. Sonkar A, et al. Biochim Biophys Acta, 2016 Feb. PMID 26581324
    3. Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins. Jakopec V, et al. Mol Cell Biol, 2012 Aug. PMID 22711988, Free PMC Article
    4. Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D. Fedyanina OS, et al. Curr Genet, 2006 Nov. PMID 17004072
    5. Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Goshima G, et al. Genes Dev, 1999 Jul 1. PMID 10398680, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IC
    Inferred by Curator
    more info
    		  
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric core domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of inner kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MIS12/MIND complex Mis12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1137753..1139618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021364.3 → NP_595454.1  MIS12/MIND complex Mis12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595454.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y738
      Conserved Domains (2) summary
      pfam05859
      Location:1 → 131
      Mis12; Mis12 protein
      cl17190
      Location:107 → 188
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version

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