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    Arhgap20 Rho GTPase activating protein 20 [ Mus musculus (house mouse) ]

    Gene ID: 244867, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgap20provided by MGI
    Official Full Name
    Rho GTPase activating protein 20provided by MGI
    Primary source
    MGI:MGI:2445175
    See related
    Ensembl:ENSMUSG00000053199 AllianceGenome:MGI:2445175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RARhoGAP; mKIAA1391; 6530403F17Rik; A530023E23Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction. Is expressed in several structures, including genitourinary system; heart; liver; lung; and thymus. Orthologous to human ARHGAP20 (Rho GTPase activating protein 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 5.6), cortex adult (RPKM 5.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap20 in Genome Data Viewer
    Location:
    9 A5.3; 9 28.62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51676651..51765158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51765351..51853059)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24131 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:51513381-51513682 Neighboring gene predicted gene, 40520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51654007-51654222 Neighboring gene Rho GTPase activating protein 20, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51674851-51675052 Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene ferredoxin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel group of multi-GAP-domain proteins. Ruan Y, et al. Mol Reprod Dev, 2008 Oct. PMID 18363199, Free PMC Article
    2. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. Katoh M, et al. Int J Oncol, 2003 Nov. PMID 14532992
    3. Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells. Curry BJ, et al. Genomics, 2004 Aug. PMID 15234003
    4. cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector. Aivatiadou E, et al. Mol Reprod Dev, 2009 Apr. PMID 18937323
    5. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis.
      Title: cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.
    2. human KIAA1391 gene and mouse Kiaa1391 gene encode RhoGAP proteins with RA domain and two ANXL repeats
      Title: Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 20
    Names
    RA and RhoGAP domain-containing protein
    rho-type GTPase-activating protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175535.5 → NP_780744.2  rho GTPase-activating protein 20

      See identical proteins and their annotated locations for NP_780744.2

      Status: VALIDATED

      Source sequence(s)
      AC140363, AC162806
      Consensus CDS
      CCDS23177.1
      UniProtKB/Swiss-Prot
      Q6IFT4, Q6ZPS4, Q8BLZ7, Q8BXI4
      UniProtKB/TrEMBL
      D3YUH8
      Related
      ENSMUSP00000065633.6, ENSMUST00000065496.12
      Conserved Domains (3) summary
      cd04402
      Location:362 → 555
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
      cd13319
      Location:84 → 180
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      pfam00788
      Location:198 → 274
      RA; Ras association (RalGDS/AF-6) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      51676651..51765158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155004.1 → XP_036010897.1  rho GTPase-activating protein 20 isoform X1

      UniProtKB/TrEMBL
      D3YUH8
      Conserved Domains (3) summary
      cd04402
      Location:283 → 476
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cd13319
      Location:5 → 101
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      cd17115
      Location:115 → 232
      RA_RHG20; Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IFT4.1 GenPept UniProtKB/Swiss-Prot:Q6IFT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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