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    NPR3 natriuretic peptide receptor 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 281358, updated on 4-Oct-2024

    Summary

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    Gene symbol
    NPR3
    Gene description
    natriuretic peptide receptor 3
    See related
    Ensembl:ENSBTAG00000007665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NPR3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (40915159..40995858, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107131571 Neighboring gene microRNA mir-12058 Neighboring gene uncharacterized LOC104975283 Neighboring gene SUB1 regulator of transcription

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A variant form of the type C atrial natriuretic peptide receptor generated by alternative RNA splicing. Mizuno T, et al. J Biol Chem, 1993 Mar 5. PMID 8444892
    2. Mutational analysis of disulfide bridges in the type C atrial natriuretic peptide receptor. Itakura M, et al. J Biol Chem, 1994 Mar 18. PMID 8132555
    3. Atrial natriuretic peptide clearance receptor. Complete sequence and functional expression of cDNA clones. Fuller F, et al. J Biol Chem, 1988 Jul 5. PMID 2837487
    4. Purification and properties of active atrial-natriuretic-peptide receptor (type C) from bovine lung. Uchida K, et al. Biochem J, 1989 Nov 1. PMID 2557006, Free PMC Article
    5. Structure of the bovine atrial natriuretic peptide receptor (type C) gene. Saheki T, et al. J Biol Chem, 1991 Jun 15. PMID 1645726

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables natriuretic peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    atrial natriuretic peptide receptor 3
    Names
    ANP-C
    ANPR-C
    ANPRC
    NPR-C
    atrial natriuretic peptide C-type receptor
    atrial natriuretic peptide clearance receptor
    atrial natriuretic peptide receptor type C
    atrionatriuretic peptide receptor C
    natriuretic peptide receptor C
    natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174127.2 → NP_776552.1  atrial natriuretic peptide receptor 3 precursor

      See identical proteins and their annotated locations for NP_776552.1

      Status: PROVISIONAL

      Source sequence(s)
      J03876
      UniProtKB/Swiss-Prot
      P10730, P20644
      Related
      ENSBTAP00000069735.1, ENSBTAT00000074857.2
      Conserved Domains (3) summary
      cd06386
      Location:50 → 442
      PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
      cd12841
      Location:471 → 503
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      pfam01094
      Location:67 → 420
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40915159..40995858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981201.2 → XP_024836969.1  atrial natriuretic peptide receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      P10730, P20644
      Conserved Domains (2) summary
      cd06386
      Location:50 → 442
      PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
      cl25995
      Location:467 → 502
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10730.2 GenPept UniProtKB/Swiss-Prot:P10730

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials