Vgf VGF nerve growth factor inducible [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Vgfprovided by RGD
Full Name: VGF nerve growth factor inducibleprovided by RGD
Primary source: RGD:69399
See related: EnsemblRapid:ENSRNOG00000001416 AllianceGenome:RGD:69399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable neuropeptide hormone activity. Involved in penile erection and regulation of neuronal synaptic plasticity. Located in neuron projection; neuronal cell body; and secretory granule membrane. Is active in synapse. Orthologous to human VGF (VGF nerve growth factor inducible). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 47.8) and Adrenal (RPKM 4.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25274004..25281803, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19637313..19645123, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22677302..22680630, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VGF: A prospective biomarker and therapeutic target for neuroendocrine and nervous system disorders.
Title: VGF: A prospective biomarker and therapeutic target for neuroendocrine and nervous system disorders.
Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models.
Title: Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models.
Sexually experienced males. VGF-derived neuropeptides presumably serve as an effector molecule to increase sexual activity following sexual arousal induction.
Title: VGF in the Medial Preoptic Nucleus Increases Sexual Activity Following Sexual Arousal Induction in Male Rats.
Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element
Title: Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.
various VGF peptides may regulate the hypothalamus-pituitary complex via specific neuroendocrine mechanisms while TLQP peptides may act at further, multiple levels via endocrine mechanisms involving the ovary.
Title: VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides?
VGF is involved in the control of metabolism and body weight homeostasis; active peptide fragments are generated from VGF, including TLQP-21, which controls reproductive function in female rats.
Title: Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: in vivo and in vitro studies.
These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages
Title: Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.
VGF expression under continuous stress is negatively regulated by dopaminergic neurons projecting from the hypothalamus.
Title: Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.
Specific VGF peptides appear to be widely represented in different gastric endocrine and other mucosal cell populations.
Title: Selective expression of TLQP-21 and other VGF peptides in gastric neuroendocrine cells and modulation by feeding.
VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and gastrointestinal tract.
Title: Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Rat70 (e-PCR), detects polymorphism
- UniSTS:226469

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in generation of precursor metabolites and energy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sexual reproduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling via neuropeptide	EXP Inferred from Experiment more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurosecretory protein VGF

Names: VGF8a protein; neurosecretory protein VGF-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395575.1 → NP_001382504.1 neurosecretory protein VGF precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P20156

UniProtKB/TrEMBL

A6J052, F1LP80

Related

ENSRNOP00000104281.1, ENSRNOT00000155118.1

Conserved Domains (1) summary

PRK14086
Location:93 → 248

dnaA; chromosomal replication initiator protein DnaA
NM_030997.2 → NP_112259.1 neurosecretory protein VGF precursor

See identical proteins and their annotated locations for NP_112259.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P20156

UniProtKB/TrEMBL

A6J052, F1LP80

Related

ENSRNOP00000050024.3, ENSRNOT00000041808.4

Conserved Domains (1) summary

PRK14086
Location:93 → 248

dnaA; chromosomal replication initiator protein DnaA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

25274004..25281803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089294.2 → XP_038945222.1 neurosecretory protein VGF isoform X1

UniProtKB/TrEMBL

F1LP80

Conserved Domains (2) summary

PRK14086
Location:143 → 298

dnaA; chromosomal replication initiator protein DnaA

cl40565
Location:280 → 358

staphy_B_SbnF; staphyloferrin B biosynthesis protein SbnF
XM_039089290.2 → XP_038945218.1 neurosecretory protein VGF isoform X1

UniProtKB/TrEMBL

F1LP80

Conserved Domains (2) summary

PRK14086
Location:143 → 298

dnaA; chromosomal replication initiator protein DnaA

cl40565
Location:280 → 358

staphy_B_SbnF; staphyloferrin B biosynthesis protein SbnF
XM_039089291.2 → XP_038945219.1 neurosecretory protein VGF isoform X1

UniProtKB/TrEMBL

F1LP80

Conserved Domains (2) summary

PRK14086
Location:143 → 298

dnaA; chromosomal replication initiator protein DnaA

cl40565
Location:280 → 358

staphy_B_SbnF; staphyloferrin B biosynthesis protein SbnF