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    Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24298, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cyp21a1provided by RGD
    Official Full Name
    cytochrome P450, family 21, subfamily a, polypeptide 1provided by RGD
    Primary source
    RGD:2461
    See related
    EnsemblRapid:ENSRNOG00000000428 AllianceGenome:RGD:2461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    21-OH; Cyp21
    Summary
    Enables steroid 21-monooxygenase activity. Involved in C21-steroid hormone metabolic process; cellular response to peptide hormone stimulus; and mineralocorticoid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 17893.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyp21a1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4028323..4031549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4020217..4026923)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4486213..4489358, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene complement C4A Neighboring gene tenascin XA, pseudogene 1 Neighboring gene uncharacterized LOC134483856 Neighboring gene uncharacterized LOC120098978 Neighboring gene activating transcription factor 6 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Steroid 21-hydroxylase expression in cultured rat astrocytes. Lovelace M, et al. Brain Res Bull, 2003 Oct 15. PMID 14519458
    2. Congenital adrenal hyperplasia. Speiser PW, et al. N Engl J Med, 2003 Aug 21. PMID 12930931
    3. Cloning of two alternatively spliced 21-hydroxylase CDNAs from rat adrenal. Zhou MY, et al. J Steroid Biochem Mol Biol, 1997 Jul. PMID 9408081
    4. Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin. Brake PB, et al. Endocrinology, 1995 Nov. PMID 7588239
    5. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Huang XJ, et al. Toxicol Lett, 2009 Dec 15. PMID 19733641

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 17-hydroxyprogesterone 21-hydroxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables progesterone 21-hydroxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables steroid 21-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid 21-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C21-steroid hormone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glucocorticoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mineralocorticoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in progesterone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    steroid 21-hydroxylase
    Names
    21-OHase
    Cytochrome P450 subfamily XXI (steroid 21-hydroxylase)
    P-450c21
    P450-C21
    cytochrome P-450c21
    cytochrome P450 21 steroid 21 hydroxylase
    cytochrome P450 XXI
    cytochrome P450, subfamily 21A, polypeptide 1
    cytochrome P450, subfamily XXI (steroid 21-hydroxylase)
    cytochrome P450-C21
    NP_476442.2
    XP_006255969.1
    XP_063135021.1
    XP_063135022.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057101.2 → NP_476442.2  steroid 21-hydroxylase

      Status: VALIDATED

      Source sequence(s)
      BX883044
      UniProtKB/Swiss-Prot
      Q64562
      UniProtKB/TrEMBL
      F1LRG0
      Related
      ENSRNOP00000037516.3, ENSRNOT00000031548.5
      Conserved Domains (1) summary
      pfam00067
      Location:31 → 474
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4028323..4031549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278952.1 → XP_063135022.1  steroid 21-hydroxylase isoform X3

    2. XM_063278951.1 → XP_063135021.1  steroid 21-hydroxylase isoform X2

    3. XM_006255907.4 → XP_006255969.1  steroid 21-hydroxylase isoform X1

      UniProtKB/Swiss-Prot
      Q64562
      Conserved Domains (1) summary
      pfam00067
      Location:31 → 473
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64562.1 GenPept UniProtKB/Swiss-Prot:Q64562

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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