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    Ptprd protein tyrosine phosphatase, receptor type, D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313278, updated on 2-Nov-2024

    Summary

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    Symbol
    Ptprdprovided by RGD
    Full Name
    protein tyrosine phosphatase, receptor type, Dprovided by RGD
    Primary source
    RGD:1561090
    See related
    EnsemblRapid:ENSRNOG00000005711 AllianceGenome:RGD:1561090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cell adhesion molecule binding activity; protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; regulation of postsynaptic density assembly; and synaptic membrane adhesion. Is active in glutamatergic synapse. Biomarker of restless legs syndrome. Human ortholog(s) of this gene implicated in coronary artery disease; diabetes mellitus; hypertension; and type 2 diabetes mellitus. Orthologous to human PTPRD (protein tyrosine phosphatase receptor type D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 355.8), Kidney (RPKM 349.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptprd in Genome Data Viewer
    Location:
    5q31
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (95093221..97415498, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (90046993..90698977, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (92862229..93514071, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486942 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 16 Neighboring gene malate dehydrogenase 2, pseudogene 1 Neighboring gene uncharacterized LOC134486943 Neighboring gene U6 spliceosomal RNA Neighboring gene component of oligomeric golgi complex 5, pseudogene 1 Neighboring gene uncharacterized LOC120103065 Neighboring gene developmentally regulated GTP binding protein 1, pseudogene 2 Neighboring gene uncharacterized LOC134486944 Neighboring gene zinc finger CCHC-type containing 9, pseudogene 3 Neighboring gene protein tyrosine phosphatase, receptor type, D like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. Morais MA, et al. J Sleep Res, 2023 Apr. PMID 36053904
    2. Effectiveness of exercise and pramipexole in the treatment of restless leg syndrome: Implications on the dopaminergic system and PTPRD. Morais MA, et al. Sleep Med, 2023 Oct. PMID 37633178
    3. Genome-wide association analysis of common genetic variants of resistant hypertension. El Rouby N, et al. Pharmacogenomics J, 2019 Jun. PMID 30237584, Free PMC Article
    4. Large scale association analysis identifies three susceptibility loci for coronary artery disease. Saade S, et al. PLoS One, 2011. PMID 22216278, Free PMC Article
    5. Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. Uetani N, et al. EMBO J, 2000 Jun 15. PMID 10856223, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome.
      Title: Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome.
    2. Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis.
      Title: Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.
    3. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
      Title: Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic membrane assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic density assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trans-synaptic signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trans-synaptic signaling by trans-synaptic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase delta
    XP_038967365.1
    XP_038967368.1
    XP_038967379.1
    XP_038967381.1
    XP_038967383.1
    XP_038967384.1
    XP_038967387.1
    XP_038967389.1
    XP_038967390.1
    XP_038967391.1
    XP_063144608.1
    XP_063144609.1
    XP_063144610.1
    XP_063144611.1
    XP_063144612.1
    XP_063144613.1
    XP_063144614.1
    XP_063144615.1
    XP_063144616.1
    XP_063144617.1
    XP_063144618.1
    XP_063144619.1
    XP_063144620.1
    XP_063144621.1
    XP_063144622.1
    XP_063144623.1
    XP_063144624.1
    XP_063144625.1
    XP_063144626.1
    XP_063144627.1
    XP_063144629.1
    XP_063144630.1
    XP_063144631.1
    XP_063144632.1
    XP_063144634.1
    XP_063144635.1
    XP_063144636.1
    XP_063144637.1
    XP_063144638.1
    XP_063144639.1
    XP_063144640.1
    XP_063144641.1
    XP_063144642.1
    XP_063144643.1
    XP_063144644.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427220.1 → NP_001414149.1  receptor-type tyrosine-protein phosphatase delta precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      95093221..97415498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288539.1 → XP_063144609.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    2. XM_063288540.1 → XP_063144610.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    3. XM_039111462.2 → XP_038967390.1  receptor-type tyrosine-protein phosphatase delta isoform X42

      UniProtKB/TrEMBL
      A0A8I6A789
      Conserved Domains (8) summary
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:916 → 1199
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1200 → 1491
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:783 → 875
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 224
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:233 → 314
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    4. XM_039111461.2 → XP_038967389.1  receptor-type tyrosine-protein phosphatase delta isoform X40

      UniProtKB/TrEMBL
      A0A8I5ZQN2
      Conserved Domains (8) summary
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:920 → 1203
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1204 → 1495
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:783 → 875
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 224
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:233 → 314
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    5. XM_063288574.1 → XP_063144644.1  receptor-type tyrosine-protein phosphatase delta isoform X41

    6. XM_063288566.1 → XP_063144636.1  receptor-type tyrosine-protein phosphatase delta isoform X27

    7. XM_063288565.1 → XP_063144635.1  receptor-type tyrosine-protein phosphatase delta isoform X26

    8. XM_063288564.1 → XP_063144634.1  receptor-type tyrosine-protein phosphatase delta isoform X25

    9. XM_063288559.1 → XP_063144629.1  receptor-type tyrosine-protein phosphatase delta isoform X21

      Related
      ENSRNOP00000089430.3, ENSRNOT00000094348.3

    10. XM_039111440.2 → XP_038967368.1  receptor-type tyrosine-protein phosphatase delta isoform X20

      UniProtKB/TrEMBL
      A0A8I6AEM0
      Conserved Domains (8) summary
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1322 → 1605
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1606 → 1897
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:1185 → 1277
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 224
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:233 → 314
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    11. XM_063288554.1 → XP_063144624.1  receptor-type tyrosine-protein phosphatase delta isoform X16

    12. XM_063288553.1 → XP_063144623.1  receptor-type tyrosine-protein phosphatase delta isoform X15

    13. XM_063288556.1 → XP_063144626.1  receptor-type tyrosine-protein phosphatase delta isoform X18

      Related
      ENSRNOP00000086806.3, ENSRNOT00000113220.3

    14. XM_063288550.1 → XP_063144620.1  receptor-type tyrosine-protein phosphatase delta isoform X11

    15. XM_039111459.2 → XP_038967387.1  receptor-type tyrosine-protein phosphatase delta isoform X39

      UniProtKB/TrEMBL
      A0A8I5ZQN2
      Conserved Domains (8) summary
      cd00063
      Location:321 → 410
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:924 → 1207
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1208 → 1499
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:787 → 879
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 224
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:237 → 318
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    16. XM_063288548.1 → XP_063144618.1  receptor-type tyrosine-protein phosphatase delta isoform X9

    17. XM_063288562.1 → XP_063144632.1  receptor-type tyrosine-protein phosphatase delta isoform X24

    18. XM_039111453.2 → XP_038967381.1  receptor-type tyrosine-protein phosphatase delta isoform X34

      UniProtKB/TrEMBL
      A0A8I5ZQN2
      Conserved Domains (7) summary
      cd00063
      Location:327 → 416
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:931 → 1214
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1215 → 1506
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 230
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:243 → 324
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    19. XM_039111456.2 → XP_038967384.1  receptor-type tyrosine-protein phosphatase delta isoform X37

      UniProtKB/TrEMBL
      A0A8I5ZQN2
      Conserved Domains (7) summary
      cd00063
      Location:327 → 416
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:928 → 1211
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1212 → 1503
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 230
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:243 → 324
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    20. XM_063288561.1 → XP_063144631.1  receptor-type tyrosine-protein phosphatase delta isoform X23

    21. XM_063288544.1 → XP_063144614.1  receptor-type tyrosine-protein phosphatase delta isoform X5

    22. XM_063288571.1 → XP_063144641.1  receptor-type tyrosine-protein phosphatase delta isoform X32

      Related
      ENSRNOP00000098524.2, ENSRNOT00000120941.2

    23. XM_063288573.1 → XP_063144643.1  receptor-type tyrosine-protein phosphatase delta isoform X38

    24. XM_063288557.1 → XP_063144627.1  receptor-type tyrosine-protein phosphatase delta isoform X19

    25. XM_063288546.1 → XP_063144616.1  receptor-type tyrosine-protein phosphatase delta isoform X7

    26. XM_039111455.2 → XP_038967383.1  receptor-type tyrosine-protein phosphatase delta isoform X36

      UniProtKB/TrEMBL
      A0A8I5ZQN2
      Conserved Domains (7) summary
      cd00063
      Location:330 → 419
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:930 → 1213
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1214 → 1505
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 233
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:246 → 327
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    27. XM_063288570.1 → XP_063144640.1  receptor-type tyrosine-protein phosphatase delta isoform X31

    28. XM_039111451.2 → XP_038967379.1  receptor-type tyrosine-protein phosphatase delta isoform X33

      UniProtKB/TrEMBL
      A0A8I5ZQN2
      Conserved Domains (7) summary
      cd00063
      Location:330 → 419
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:934 → 1217
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1218 → 1509
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 233
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:246 → 327
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    29. XM_063288568.1 → XP_063144638.1  receptor-type tyrosine-protein phosphatase delta isoform X29

    30. XM_063288572.1 → XP_063144642.1  receptor-type tyrosine-protein phosphatase delta isoform X35

    31. XM_063288569.1 → XP_063144639.1  receptor-type tyrosine-protein phosphatase delta isoform X30

    32. XM_063288567.1 → XP_063144637.1  receptor-type tyrosine-protein phosphatase delta isoform X28

    33. XM_063288560.1 → XP_063144630.1  receptor-type tyrosine-protein phosphatase delta isoform X22

    34. XM_063288555.1 → XP_063144625.1  receptor-type tyrosine-protein phosphatase delta isoform X17

    35. XM_063288549.1 → XP_063144619.1  receptor-type tyrosine-protein phosphatase delta isoform X10

    36. XM_063288547.1 → XP_063144617.1  receptor-type tyrosine-protein phosphatase delta isoform X8

    37. XM_039111463.2 → XP_038967391.1  receptor-type tyrosine-protein phosphatase delta isoform X4

      UniProtKB/TrEMBL
      A0A8I6A6R5
      Conserved Domains (9) summary
      cd00063
      Location:330 → 419
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1358 → 1641
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1642 → 1933
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam00041
      Location:720 → 819
      fn3; Fibronectin type III domain
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:1207 → 1299
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 233
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:246 → 327
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    38. XM_039111437.2 → XP_038967365.1  receptor-type tyrosine-protein phosphatase delta isoform X14

      UniProtKB/TrEMBL
      A0A8I6A1V1
      Conserved Domains (8) summary
      cd00063
      Location:330 → 419
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1341 → 1624
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1625 → 1916
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam00041
      Location:720 → 819
      fn3; Fibronectin type III domain
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:39 → 43
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:134 → 233
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:246 → 327
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    39. XM_063288542.1 → XP_063144612.1  receptor-type tyrosine-protein phosphatase delta isoform X2

    40. XM_063288543.1 → XP_063144613.1  receptor-type tyrosine-protein phosphatase delta isoform X3

    41. XM_063288552.1 → XP_063144622.1  receptor-type tyrosine-protein phosphatase delta isoform X13

    42. XM_063288545.1 → XP_063144615.1  receptor-type tyrosine-protein phosphatase delta isoform X6

    43. XM_063288551.1 → XP_063144621.1  receptor-type tyrosine-protein phosphatase delta isoform X12

    44. XM_063288538.1 → XP_063144608.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    45. XM_063288541.1 → XP_063144611.1  receptor-type tyrosine-protein phosphatase delta isoform X1

      Related
      ENSRNOP00000091521.3, ENSRNOT00000119354.3
    Nucleotide Protein Strain
    Heading Accession and Version

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