Pygm glycogen phosphorylase, muscle associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pygmprovided by RGD
Official Full Name: glycogen phosphorylase, muscle associatedprovided by RGD
Primary source: RGD:3461
See related: EnsemblRapid:ENSRNOG00000021090 AllianceGenome:RGD:3461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Muscpho
Summary: Enables carbohydrate binding activity; glycogen phosphorylase activity; and heterocyclic compound binding activity. Involved in several processes, including glycogen catabolic process; intracellular calcium ion homeostasis; and response to cAMP. Located in sarcoplasmic reticulum. Used to study cholestasis. Human ortholog(s) of this gene implicated in glycogen storage disease V. Orthologous to human PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 14829.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213119805..213134622)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203690550..203705369)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221756325..221771142)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that PYGM and RAC1 are altered in the dorsolateral prefrontal cortex in chronic schizophrenia and are controlled by NMDA signaling in the rodent cortex and cortical astrocytes suggesting an altered NMDA-dependent glycogenolysis in astrocytes in schizophrenia.
Title: The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140670 (e-PCR)
- UniSTS:222738

D1Wox28 (e-PCR)
- UniSTS:118100

d1mgh11 (e-PCR)
- UniSTS:121447

RH128350 (e-PCR)
- UniSTS:211658

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	ISO Inferred from Sequence Orthology more info
enables glycogen phosphorylase activity	TAS Traceable Author Statement more info	PubMed
enables organic cyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glycogen phosphorylase, muscle form

Names: Phosphorylase glycogen; Phosphorylase, glycogen; muscle (McArdle syndrome); muscle (McArdle syndrome); muscle glycogen phosphorylase; myophosphorylase; phosphorylase, glycogen, muscle

NP_036770.1

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.