Prrt1 proline-rich transmembrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prrt1provided by RGD
Official Full Name: proline-rich transmembrane protein 1provided by RGD
Primary source: RGD:1359348
See related: EnsemblRapid:ENSRNOG00000000433 AllianceGenome:RGD:1359348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ng5; DSPD1; Orf31; SynDIG4
Summary: Predicted to enable identical protein binding activity and signaling receptor regulator activity. Predicted to be involved in several processes, including long-term synaptic depression; protein localization to cell surface; and regulation of AMPA receptor activity. Predicted to act upstream of or within several processes, including learning or memory; long-term synaptic potentiation; and synapse organization. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human PRRT1 (proline rich transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 29.8), Brain (RPKM 21.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4122565..4126386, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4117957..4121643, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4392605..4396271)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that, although SynDIG4 shares sequence similarity with SynDIG1, it might act through a unique mechanism as an auxiliary factor for extrasynaptic GluA1-containing AMPA receptors
Title: Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487767

NoName (e-PCR)
- UniSTS:488540

RH131882 (e-PCR)
- UniSTS:215165

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proline-rich transmembrane protein 1

Names: dispanin subfamily D member 1; synapse differentiation-induced protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032285.2 → NP_001027456.1 proline-rich transmembrane protein 1

See identical proteins and their annotated locations for NP_001027456.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q6MG82

UniProtKB/TrEMBL

A6KTI9

Related

ENSRNOP00000000495.4, ENSRNOT00000000495.8

Conserved Domains (1) summary

pfam04505
Location:215 → 285

CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4122565..4126386 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279358.1 → XP_063135428.1 proline-rich transmembrane protein 1 isoform X3
XM_063279357.1 → XP_063135427.1 proline-rich transmembrane protein 1 isoform X3
XM_006255980.4 → XP_006256042.1 proline-rich transmembrane protein 1 isoform X1

Related

ENSRNOP00000098032.2, ENSRNOT00000120342.2

Conserved Domains (1) summary

pfam04505
Location:301 → 371

CD225; Interferon-induced transmembrane protein
XM_006255981.5 → XP_006256043.1 proline-rich transmembrane protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A292