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    C1qtnf7 C1q and TNF related 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305423, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C1qtnf7provided by RGD
    Official Full Name
    C1q and TNF related 7provided by RGD
    Primary source
    RGD:1306978
    See related
    EnsemblRapid:ENSRNOG00000005094 AllianceGenome:RGD:1306978
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adig; Ctrp7
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in extracellular space. Orthologous to human C1QTNF7 (C1q and TNF related 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 110.6), Heart (RPKM 42.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C1qtnf7 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71680415..71792931, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67467888..67580477, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (72011518..72122257, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene F-box and leucine-rich repeat protein 5 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene protein BEX4-like Neighboring gene iron-sulfur cluster assembly 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway. Bi J, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Dec 25. PMID 36514218, Free PMC Article
    2. Age-associated loss in adiponectin-activation by caloric restriction: lack of compensation by enhanced inducibility of adiponectin paralogs CTRP2 and CTRP7. Rohrbach S, et al. Mol Cell Endocrinol, 2007 Oct 15. PMID 17716811
    3. A family of Acrp30/adiponectin structural and functional paralogs. Wong GW, et al. Proc Natl Acad Sci U S A, 2004 Jul 13. PMID 15231994, Free PMC Article
    4. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Wong GW, et al. Biochem J, 2008 Dec 1. PMID 18783346, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway.
      Title: Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway.
    2. The purpose of the current study was to investigate age-dependent effects of caloric restriction on the release of adiponectin, expression and activation of adiponectin-related signaling and on parameters of altered insulin sensitivity.
      Title: Age-associated loss in adiponectin-activation by caloric restriction: lack of compensation by enhanced inducibility of adiponectin paralogs CTRP2 and CTRP7.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 7
    Names
    C1q and tumor necrosis factor related protein 7
    adiponectin g

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107221.1 → NP_001100691.1  complement C1q tumor necrosis factor-related protein 7 precursor

      See identical proteins and their annotated locations for NP_001100691.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A0A3B0IP30, B2RYB7, F1M6V5
      Conserved Domains (2) summary
      pfam00386
      Location:149 → 273
      C1q; C1q domain
      pfam01391
      Location:59 → 108
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      71680415..71792931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091942.2 → XP_038947870.1  complement C1q tumor necrosis factor-related protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A3B0IP30, B2RYB7, F1M6V5
      Conserved Domains (2) summary
      pfam00386
      Location:149 → 273
      C1q; C1q domain
      pfam01391
      Location:59 → 108
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_006251073.5 → XP_006251135.1  complement C1q tumor necrosis factor-related protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2QC08, A0A3B0IP30
      Related
      ENSRNOP00000061160.3, ENSRNOT00000064495.5
      Conserved Domains (2) summary
      pfam00386
      Location:156 → 280
      C1q; C1q domain
      pfam01391
      Location:66 → 115
      Collagen; Collagen triple helix repeat (20 copies)

    3. XM_039091943.2 → XP_038947871.1  complement C1q tumor necrosis factor-related protein 7 isoform X3

      Conserved Domains (2) summary
      pfam00386
      Location:74 → 198
      C1q; C1q domain
      pfam01391
      Location:8 → 62
      Collagen; Collagen triple helix repeat (20 copies)

    4. XM_006251075.4 → XP_006251137.1  complement C1q tumor necrosis factor-related protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006251137.1

      UniProtKB/TrEMBL
      A0A3B0IP30, B2RYB7, F1M6V5
      Conserved Domains (2) summary
      pfam00386
      Location:149 → 273
      C1q; C1q domain
      pfam01391
      Location:59 → 108
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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