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    Grb10 growth factor receptor bound protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498416, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Grb10provided by RGD
    Official Full Name
    growth factor receptor bound protein 10provided by RGD
    Primary source
    RGD:1566234
    See related
    EnsemblRapid:ENSRNOG00000004290 AllianceGenome:RGD:1566234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566234
    Summary
    Enables insulin receptor binding activity. Involved in insulin receptor signaling pathway; negative regulation of glycogen biosynthetic process; and positive regulation of phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 551.4), Adrenal (RPKM 499.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grb10 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90708653..90816399, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86495051..86602800, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (92021851..92122249, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096666 Neighboring gene fidgetin-like 1 Neighboring gene dopa decarboxylase Neighboring gene uncharacterized LOC120096667 Neighboring gene uncharacterized LOC102552764 Neighboring gene uncharacterized LOC134481784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats. Ma L, et al. J Neuroendocrinol, 2013 Jul. PMID 23614367
    2. MiR199a is implicated in embryo implantation by regulating Grb10 in rat. Xia HF, et al. Reproduction, 2014 Jan. PMID 24149516
    3. Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway. Mounier C, et al. Mol Cell Endocrinol, 2001 Feb 28. PMID 11223174
    4. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Liu M, et al. Cell Metab, 2014 Jun 3. PMID 24746805, Free PMC Article
    5. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Depetris RS, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648926, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In rat uterus, enforced miR199a expression suppresses cell proliferation partially through targeting Grb10.
      Title: MiR199a is implicated in embryo implantation by regulating Grb10 in rat.
    2. findings indicate that endogenous overexpression of Grb10 functions as a suppressor of the IGF1-IR pathway, which may represent an important mechanism for regulating cognitive disorder in diabetes
      Title: Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor complex adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor complex adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of D-glucose import IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to insulin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    growth factor receptor-bound protein 10
    Names
    GRB10 adapter protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401403.1 → NP_001388332.1  growth factor receptor-bound protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P0CE43

    2. NM_001401404.1 → NP_001388333.1  growth factor receptor-bound protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JYJ1
      Related
      ENSRNOP00000070674.1, ENSRNOT00000085175.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      90708653..90816399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273491.1 → XP_063129561.1  growth factor receptor-bound protein 10 isoform X8

    2. XM_063273489.1 → XP_063129559.1  growth factor receptor-bound protein 10 isoform X6

    3. XM_063273488.1 → XP_063129558.1  growth factor receptor-bound protein 10 isoform X5

      UniProtKB/Swiss-Prot
      P0CE43

    4. XM_063273487.1 → XP_063129557.1  growth factor receptor-bound protein 10 isoform X5

      UniProtKB/Swiss-Prot
      P0CE43

    5. XM_063273492.1 → XP_063129562.1  growth factor receptor-bound protein 10 isoform X8

    6. XM_063273486.1 → XP_063129556.1  growth factor receptor-bound protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYJ1

    7. XM_039092313.2 → XP_038948241.1  growth factor receptor-bound protein 10 isoform X3

      Related
      ENSRNOP00000099840.1, ENSRNOT00000153825.1
      Conserved Domains (4) summary
      cd10415
      Location:529 → 636
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:328 → 450
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:208 → 299
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:468 → 509
      BPS; BPS (Between PH and SH2)

    8. XM_063273490.1 → XP_063129560.1  growth factor receptor-bound protein 10 isoform X7

    9. XM_039092307.2 → XP_038948235.1  growth factor receptor-bound protein 10 isoform X1

      Related
      ENSRNOP00000048487.5, ENSRNOT00000044726.6
      Conserved Domains (4) summary
      cd10415
      Location:584 → 691
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:383 → 505
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:266 → 354
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:523 → 564
      BPS; BPS (Between PH and SH2)

    10. XM_039092311.2 → XP_038948239.1  growth factor receptor-bound protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A9M1XG80
      Related
      ENSRNOP00000100101.1, ENSRNOT00000165114.1
      Conserved Domains (4) summary
      cd10415
      Location:529 → 636
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:328 → 450
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:211 → 299
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:468 → 509
      BPS; BPS (Between PH and SH2)

    11. XM_039092308.2 → XP_038948236.1  growth factor receptor-bound protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYJ1
      Conserved Domains (4) summary
      cd10415
      Location:529 → 636
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:328 → 450
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:211 → 299
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:468 → 509
      BPS; BPS (Between PH and SH2)

    12. XM_039092309.2 → XP_038948237.1  growth factor receptor-bound protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYJ1
      Conserved Domains (4) summary
      cd10415
      Location:529 → 636
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:328 → 450
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:211 → 299
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:468 → 509
      BPS; BPS (Between PH and SH2)

    13. XM_039092315.2 → XP_038948243.1  growth factor receptor-bound protein 10 isoform X5

      UniProtKB/Swiss-Prot
      P0CE43
      Conserved Domains (4) summary
      cd10415
      Location:492 → 599
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:291 → 413
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:174 → 262
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:431 → 472
      BPS; BPS (Between PH and SH2)

    14. XM_039092316.2 → XP_038948244.1  growth factor receptor-bound protein 10 isoform X5

      UniProtKB/Swiss-Prot
      P0CE43
      Conserved Domains (4) summary
      cd10415
      Location:492 → 599
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:291 → 413
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:174 → 262
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:431 → 472
      BPS; BPS (Between PH and SH2)

    15. XM_039092310.2 → XP_038948238.1  growth factor receptor-bound protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYJ1
      Conserved Domains (4) summary
      cd10415
      Location:529 → 636
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:328 → 450
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:211 → 299
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:468 → 509
      BPS; BPS (Between PH and SH2)

    16. XM_039092317.2 → XP_038948245.1  growth factor receptor-bound protein 10 isoform X5

      UniProtKB/Swiss-Prot
      P0CE43
      Conserved Domains (4) summary
      cd10415
      Location:492 → 599
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:291 → 413
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:174 → 262
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:431 → 472
      BPS; BPS (Between PH and SH2)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109093.1: Suppressed sequence

      Description
      NM_001109093.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CE43.1 GenPept UniProtKB/Swiss-Prot:P0CE43

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