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    Ints13 integrator complex subunit 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690728, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ints13provided by RGD
    Official Full Name
    integrator complex subunit 13provided by RGD
    Primary source
    RGD:1592236
    See related
    EnsemblRapid:ENSRNOG00000001808 AllianceGenome:RGD:1592236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Asun
    Summary
    Predicted to be involved in centrosome localization and regulation of mitotic cell cycle. Predicted to act upstream of or within mitotic spindle organization and protein localization to nuclear envelope. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of integrator complex. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 236.0), Heart (RPKM 163.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints13 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181190438..181222235, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179459740..179491541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180854988..180887095, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor, type 2 Neighboring gene uncharacterized LOC134486658 Neighboring gene uncharacterized LOC134486659 Neighboring gene E3 SUMO-protein ligase NSE2-like Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Jodoin JN, et al. Mol Biol Cell, 2012 Dec. PMID 23097494, Free PMC Article
    2. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Lee LA, et al. Dev Cell, 2005 Mar. PMID 15737938
    3. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 13
    Names
    asunder, spermatogenesis regulator homolog (Drosphila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109608.1 → NP_001103078.1  integrator complex subunit 13 isoform 2

      See identical proteins and their annotated locations for NP_001103078.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6IN19, D4A6N9
      Conserved Domains (1) summary
      pfam10221
      Location:7 → 690
      DUF2151; Cell cycle and development regulator

    2. NM_001398932.1 → NP_001385861.1  integrator complex subunit 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOP00000061847.3, ENSRNOT00000065730.3
      Conserved Domains (1) summary
      pfam10221
      Location:4 → 692
      DUF2151; Cell cycle and development regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      181190438..181222235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108388.2 → XP_038964316.1  integrator complex subunit 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWB2, A6IN18, D4A6N9
      Related
      ENSRNOP00000083691.1, ENSRNOT00000118399.2
      Conserved Domains (1) summary
      pfam10221
      Location:4 → 692
      DUF2151; Cell cycle and development regulator

    2. XM_063286723.1 → XP_063142793.1  integrator complex subunit 13 isoform X2

    RNA

    1. XR_005503317.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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