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    CYC2 oxidoreductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854202, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYC2
    Official Full Name
    oxidoreductase
    Primary source
    SGD:S000005563
    Locus tag
    YOR037W
    See related
    AllianceGenome:SGD:S000005563; FungiDB:YOR037W; VEuPathDB:YOR037W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxidoreductase activity. Involved in cytochrome c-heme linkage and mitochondrial membrane organization. Is extrinsic component of mitochondrial inner membrane. Orthologous to human CYB5RL (cytochrome b5 reductase like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CYC2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (401555..402655)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene She4p Neighboring gene SNAP receptor PEP12 Neighboring gene Hir2p Neighboring gene casein kinase 2 regulatory subunit CKB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyc2p is required for maintaining ionic stability and efficient cytochrome c import and mitochondrial function in Saccharomyces cerevisiae. Pearce DA, et al. FEBS Lett, 1998 Nov 20. PMID 9845343
    2. CYC2 encodes a factor involved in mitochondrial import of yeast cytochrome c. Dumont ME, et al. Mol Cell Biol, 1993 Oct. PMID 8413243, Free PMC Article
    3. Yeast cytochrome c-specific protein-lysine methyltransferase: coordinate regulation with cytochrome c and activities in cyc mutants. Liao HN, et al. J Bacteriol, 1979 Jun. PMID 222727, Free PMC Article
    4. The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductase. Corvest V, et al. Mol Microbiol, 2012 Mar. PMID 22257001
    5. Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases. Bernard DG, et al. J Biol Chem, 2003 Dec 12. PMID 14514677

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyc2p catalyses the NAD(P)H-dependent reduction of hemin, and interacts with CCHL and apoforms of cytochrome c and c1.
      Title: The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductase.
    2. in vivo, Cyc2p interacts with cytochrome c heme lyase and is involved in the reduction of heme prior to its ligation to apocytochrome c by CCHL
      Title: Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytochrome c-heme linkage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxidoreductase
    NP_014680.2
    • Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      401555..402655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183456.1 → NP_014680.2  TPA: oxidoreductase [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A4, P38909
      UniProtKB/TrEMBL
      A6ZNP2, B3LJ90, C7GLG6, C8ZHZ9, N1P2Y8
      Conserved Domains (1) summary
      cd06183
      Location:68 → 365
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38909.3

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