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    MKC7 aspartyl protease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851722, updated on 17-May-2024

    Summary

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    Gene symbol
    MKC7
    Gene description
    aspartyl protease
    Primary source
    FungiDB:YDR144C
    Locus tag
    YDR144C
    See related
    SGD:S000002551; AllianceGenome:SGD:S000002551; VEuPathDB:YDR144C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YPS2
    Summary
    Enables aspartic-type endopeptidase activity. Involved in fungal-type cell wall organization; proteolysis; and signal transduction involved in filamentous growth. Located in fungal-type cell wall. Human ortholog(s) of this gene implicated in Alzheimer's disease; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension (multiple); and portal hypertension. Orthologous to several human genes including BACE2 (beta-secretase 2); PGA5 (pepsinogen A5); and PGC (progastricsin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MKC7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (744311..746101, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex7p Neighboring gene ubiquitin-protein ligase SAN1 Neighboring gene Taf12p Neighboring gene DNA-binding transcription factor SWI5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). Komano H, et al. J Biol Chem, 1999 Aug 20. PMID 10446224
    2. Heterologous expression of human cholecystokinin in Saccharomyces cerevisiae. Evidence for a lysine-specific endopeptidase in the yeast secretory pathway. Rourke IJ, et al. J Biol Chem, 1997 Apr 11. PMID 9092503
    3. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. Komano H, et al. J Biol Chem, 1998 Nov 27. PMID 9822624
    4. Expression, processing and secretion of a proteolytically-sensitive insect diuretic hormone by Saccharomyces cerevisiae requires the use of a yeast strain lacking genes encoding the Yap3 and Mkc7 endoproteases found in the secretory pathway. Copley KS, et al. Biochem J, 1998 Mar 15. PMID 9494104, Free PMC Article
    5. Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases. Zhang W, et al. Biochim Biophys Acta, 1997 Nov 27. PMID 9409808

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction involved in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aspartyl protease
    NP_010428.3
    • GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      744311..746101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180451.3 → NP_010428.3  TPA: aspartyl protease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010428.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSC7, P53379
      UniProtKB/TrEMBL
      A0A8H8UN53, G2WAP4, N1PAE2
      Conserved Domains (1) summary
      cd05474
      Location:79 → 470
      SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53379.2

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