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    pol1 DNA polymerase alpha catalytic subunit [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543629, updated on 22-Jun-2024

    Summary

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    Gene symbol
    pol1
    Gene description
    DNA polymerase alpha catalytic subunit
    Locus tag
    SPOM_SPAC3H5.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    polA; swi7
    Old locus tag
    SPAC3H5.06c
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    Genomic context

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    See pol1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (3430955..3436241)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene WD repeat-containing protein Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L7b Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS11 Neighboring gene U5 snRNP-associated protein Aar2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. D'Urso G, et al. J Cell Sci, 1995 Sep. PMID 8537450
    2. DNA polymerase-alpha is essential for mating-type switching in fission yeast. Singh J, et al. Nature, 1993 Jan 21. PMID 8423854
    3. In vivo phosphorylation, mitotic behavior, and nuclear binding of the catalytic subunit of DNA polymerase alpha in fission yeast. Bouvier D, et al. Exp Cell Res, 1993 Jul. PMID 8319772
    4. Studies of Schizosaccharomyces pombe DNA polymerase alpha at different stages of the cell cycle. Park H, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501454, Free PMC Article
    5. Chromodomain protein Swi6-mediated role of DNA polymerase alpha in establishment of silencing in fission Yeast. Ahmed S, et al. J Biol Chem, 2001 Dec 21. PMID 11581276

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fen-1 and Swi-7 proteins act together in the S-phase alkylation damage response in S. pombe.
      Title: DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
    2. GINS functions in a pathway that involves Cdc45 and is necessary for DNA polymerase epsilon chromatin binding, but a separate pathway sets up the chromatin association of DNA polymerase alpha.
      Title: GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene conversion at mating-type locus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear cell cycle DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase alpha catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3430955..3436241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019610.3 → NP_594186.1  DNA polymerase alpha catalytic subunit [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594186.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P28040, Q9UTY1
      Conserved Domains (5) summary
      cd05776
      Location:522 → 757
      DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
      cd05532
      Location:829 → 1218
      POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
      TIGR00592
      Location:40 → 1200
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1238 → 1403
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
      pfam12254
      Location:15 → 78
      DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    1712310A.1

    Gene LinkOut

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