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    pca1 metacaspase Pca1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538976, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pca1
    Official Full Name
    metacaspase Pca1
    Primary source
    PomBase:SPCC1840.04
    Locus tag
    SPOM_SPCC1840.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pca1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003421.2 (2263967..2267305)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene karyopherin/importin beta family nuclear import signal receptor Sal3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phosphoglucomutase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F0-ATPase delta subunit atp5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe). Agus HH, et al. FEMS Yeast Res, 2020 Jun 1. PMID 32347926
    2. Overexpression of a metacaspase gene stimulates cell growth and stress response in Schizosaccharomyces pombe. Lim HW, et al. Can J Microbiol, 2007 Aug. PMID 17898859
    3. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
    4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe).
      Title: Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    metacaspase Pca1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2263967..2267305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023493.3 → NP_588503.1  metacaspase Pca1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588503.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74477
      Conserved Domains (3) summary
      pfam00656
      Location:130 → 421
      Peptidase_C14; Caspase domain
      pfam12273
      Location:2 → 86
      RCR; Chitin synthesis regulation, resistance to Congo red
      pfam15240
      Location:22 → 120
      Pro-rich; Proline-rich
    Nucleotide Protein
    Heading Accession and Version

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