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    SPO12 Spo12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856557, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPO12
    Official Full Name
    Spo12p
    Primary source
    SGD:S000001195
    Locus tag
    YHR152W
    See related
    AllianceGenome:SGD:S000001195; FungiDB:YHR152W; VEuPathDB:YHR152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SDB21
    Summary
    Involved in meiosis I; negative regulation of protein localization to nucleolus; and positive regulation of exit from mitosis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPO12 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (401434..401955)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Pex28p Neighboring gene Mtc6p Neighboring gene Spo16p Neighboring gene Rtt107p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new mapping method employing a meiotic rec-mutant of yeast. Klapholz S, et al. Genetics, 1982 Mar. PMID 6749597, Free PMC Article
    2. The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase. Nakatsukasa K, et al. FEBS Lett, 2018 May. PMID 29683484
    3. Genetic analysis of apomictic wine yeasts. Castrejón F, et al. Curr Genet, 2004 Apr. PMID 14760507
    4. Nuclear import of Spo12p, a protein essential for meiosis. Chaves SR, et al. J Biol Chem, 2001 May 25. PMID 11278742
    5. A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene. Molero G, et al. J Bacteriol, 1993 Oct. PMID 8407833, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Notably, Spo12 is degraded in S phase even in the absence of Tom1 and Cdh1, suggesting that an additional E3 ligase(s) also mediates Spo12 degradation
      Title: The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to nucleolus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spo12p
    NP_012022.1
    • Nucleolar hypothetical protein; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      401434..401955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179283.1 → NP_012022.1  TPA: Spo12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLA1, P17123
      UniProtKB/TrEMBL
      A6ZT60, B3LSR6, B5VK81, C7GJY6, C8Z9U9, N1P2W4
      Conserved Domains (1) summary
      pfam05032
      Location:117 → 151
      Spo12; Spo12 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17123.1

    Gene LinkOut

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