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    CTS1 chitinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850992, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CTS1
    Official Full Name
    chitinase
    Primary source
    SGD:S000004276
    Locus tag
    YLR286C
    See related
    AllianceGenome:SGD:S000004276; FungiDB:YLR286C; VEuPathDB:YLR286C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCW2
    Summary
    Enables endochitinase activity. Involved in septum digestion after cytokinesis. Located in cellular bud neck; extracellular region; and fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CTS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (708448..710136, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S30A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors. Hurtado-Guerrero R, et al. Chem Biol, 2007 May. PMID 17524989
    2. Endochitinase, a mannan-associated enzyme from Saccharomyces cerevisiae. Correa JU, et al. J Biol Chem, 1982 Feb 10. PMID 6799506
    3. Chitinase is required for cell separation during growth of Saccharomyces cerevisiae. Kuranda MJ, et al. J Biol Chem, 1991 Oct 15. PMID 1918080
    4. Multicellularity makes somatic differentiation evolutionarily stable. Wahl ME, et al. Proc Natl Acad Sci U S A, 2016 Jul 26. PMID 27402737, Free PMC Article
    5. Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae. Oud B, et al. Proc Natl Acad Sci U S A, 2013 Nov 5. PMID 24145419, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Therefore, Ace2 and Swi5 are two negative regulators of ethanol yield during static fermentation of yeast cells, and both CTS1 and RPS4a are major effectors mediating these two transcription factors in regulating ethanol production.
      Title: The transcription factor Ace2 and its paralog Swi5 regulate ethanol production during static fermentation through their targets Cts1 and Rps4a in Saccharomyces cerevisiae.
    2. Sec14 function was required for the route followed by Bgl2, whereas trafficking of other secreted proteins, including Hsp150, Cts1, Scw4, Scw10, Exg1, Cis3, and Ygp1, still occurred, indicating Sec14 regulates specific trans-Golgi export pathways.
      Title: Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endochitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in nuclear envelope HDA PubMed 

    General protein information

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    Preferred Names
    chitinase
    NP_013388.1
    • Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      708448..710136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182173.1 → NP_013388.1  TPA: chitinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYT1, P29028, P29029
      UniProtKB/TrEMBL
      G2WJA9, N1P713
      Conserved Domains (2) summary
      pfam03427
      Location:503 → 539
      CBM_19; Carbohydrate binding domain (family 19)
      cd02877
      Location:27 → 306
      GH18_hevamine_XipI_class_III; This conserved domain family includes xylanase inhibitor Xip-I, and the class III plant chitinases such as hevamine, concanavalin B, and PPL2, all of which have a glycosyl hydrolase family 18 (GH18) domain. Hevamine is a class III endochitinase that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29029.2

    Gene LinkOut

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