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    GIM4 tubulin-binding prefolding complex subunit GIM4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856715, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GIM4
    Official Full Name
    tubulin-binding prefolding complex subunit GIM4
    Primary source
    SGD:S000000729
    Locus tag
    YEL003W
    See related
    AllianceGenome:SGD:S000000729; FungiDB:YEL003W; VEuPathDB:YEL003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PFD2
    Summary
    Enables tubulin binding activity. Involved in tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GIM4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_001137.3 (148176..148599)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Vab2p Neighboring gene Yea4p Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase Neighboring gene Irc22p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Absence of Gim proteins, but not GimC complex, alters stress-induced transcription. Amorim AF, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jul. PMID 28457997
    2. Prefoldin 2 contributes to mitochondrial morphology and function. Tahmaz I, et al. BMC Biol, 2023 Sep 12. PMID 37697385, Free PMC Article
    3. Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling. Pesce CG, et al. Mol Syst Biol, 2018 Apr 4. PMID 29618636, Free PMC Article
    4. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Brew CT, et al. Genetics, 2002 Nov. PMID 12454057, Free PMC Article
    5. Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism. Matmati N, et al. Mol Cell Biol, 2020 May 28. PMID 32205408, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin-binding prefolding complex subunit GIM4
    NP_010913.2
    • Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      148176..148599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178818.1 → NP_010913.2  TPA: tubulin-binding prefolding complex subunit GIM4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010913.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBP1, D3DLP4, P40005
      UniProtKB/TrEMBL
      C7GKH6, C8Z6Z6, N1P3V9
      Conserved Domains (1) summary
      pfam01920
      Location:9 → 110
      Prefoldin_2; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40005.2

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