U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cut23 anaphase-promoting complex TPR lobe subcomplex subunit Apc8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542880, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cut23
    Official Full Name
    anaphase-promoting complex TPR lobe subcomplex subunit Apc8
    Primary source
    PomBase:SPAC6F12.14
    Locus tag
    SPOM_SPAC6F12.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    apc8
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cut23 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1340221..1342448)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene geranyltranstransferase Fps1 Neighboring gene ncRNA Neighboring gene anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6 Neighboring gene TRAMP complex ATP-dependent RNA helicase subunit Mtr4 Neighboring gene ncRNA Neighboring gene cleavage and polyadenylation specificity factor complex subunit Rna14

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis. May KM, et al. J Cell Biol, 2002 Jan 7. PMID 11777938, Free PMC Article
    2. An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast. Horikoshi Y, et al. Cell Cycle, 2013 Mar 15. PMID 23442800, Free PMC Article
    3. Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses. Yamashita YM, et al. Genes Cells, 1999 Aug. PMID 10526233
    4. Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase. Reynolds N, et al. J Cell Sci, 2003 Apr 1. PMID 12615979
    5. Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. Kimata Y, et al. J Cell Sci, 2008 Apr 1. PMID 18354085

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    anaphase-promoting complex TPR lobe subcomplex subunit Apc8

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1340221..1342448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018730.3 → NP_593300.1  anaphase-promoting complex TPR lobe subcomplex subunit Apc8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593300.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94556
      Conserved Domains (4) summary
      COG0457
      Location:258 → 532
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:374 → 400
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:338 → 371
      TPR_1; Tetratricopeptide repeat
      pfam04049
      Location:19 → 155
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous