CDC37 Cdc37p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC37
Gene description: Cdc37p
Primary source: FungiDB:YDR168W
Locus tag: YDR168W
See related: SGD:S000002575; AllianceGenome:SGD:S000002575; VEuPathDB:YDR168W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SMO1
Summary: Enables unfolded protein binding activity. Involved in several processes, including osmosensory signaling MAPK cascade; protein stabilization; and spindle pole body duplication. Located in cytoplasm. Orthologous to several human genes including CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CDC37 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (790328..791848)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

unusual stability of this Cak1:Cdc37 association may partly reflect unique structural features of the fungal Cak1
Title: Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).
Studies propose that Sic1, Cdc37, and Hsp82 may orchestrate parts of the cellular starvation response by regulating transcription factor- and kinase activities.
Title: Quantitative proteomics identifies unanticipated regulators of nitrogen- and glucose starvation.
Kss1p interacts physically with Cdc37p
Title: Cdc37p is involved in osmoadaptation and controls high osmolarity-induced cross-talk via the MAP kinase Kss1p.
Cdc37p is a part of chaperone system that determins molybdate resistance in Saccharomyces cerevisiae.
Title: The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae.
There are at least 38 genes having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37.
Title: Multiple kinases and system robustness: a link between Cdc37 and genome integrity.
During cell wall stress, the interaction between Cdc37p, Hog1p, and Hsp90 is crucial for Slt2p-dependent downstream responses to high osmotic and cell wall stress, respectively.
Title: Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p).
Cdc37 has a general role in kinome biogenesis
Title: Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular hyperosmotic response	IPI Inferred from Physical Interaction more info	PubMed
involved_in fungal-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle pole body duplication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cdc37p

NP_010452.1

Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

790328..791848

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180475.1 → NP_010452.1 TPA: Cdc37p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010452.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSE8, P06101, Q04132

UniProtKB/TrEMBL

A6ZYC6, B3LGB6, B5VG63, C7GQF1, C8Z581, G2WAR6, N1P8B5

Conserved Domains (3) summary

smart01071
Location:2 → 183

CDC37_N; Cdc37 N terminal kinase binding

smart01069
Location:389 → 490

CDC37_C; Cdc37 C terminal domain

smart01070
Location:207 → 368

CDC37_M; Cdc37 Hsp90 binding domain