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    hat1 histone acetyltransferase Hat1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542502, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hat1
    Official Full Name
    histone acetyltransferase Hat1
    Primary source
    PomBase:SPAC139.06
    Locus tag
    SPOM_SPAC139.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    kat1; SPAC23C4.01
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    Genomic context

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    See hat1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003424.3 (1030220..1031941)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene L-saccharopine oxidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene succinate-semialdehyde dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene coronin Crn1 Neighboring gene haspin-like kinase Hrk1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. Tong K, et al. Eukaryot Cell, 2012 Sep. PMID 22771823, Free PMC Article
    2. Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair. Benson LJ, et al. J Biol Chem, 2007 Jan 12. PMID 17052979
    3. A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice. Pai CC, et al. Nat Commun, 2014 Jun 9. PMID 24909977, Free PMC Article
    4. Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly. Subramanian L, et al. Open Biol, 2014 Apr 30. PMID 24789708, Free PMC Article
    5. Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase. Kaufmann I, et al. Mol Cell Biol, 2010 Jul. PMID 20404084, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hat1 associates with Mis16 and acetylates lysines 5 and 12 of histone H4. Deletion of Hat1 causes loss of silencing at telomeres.
      Title: Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
    2. the role of Hat1 in DNA damage repair is evolutionarily conserved, the ability of H3 acetylation to compensate for Hat1 deletion appears to be more variable
      Title: Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K8 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase Hat1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1030220..1031941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018570.3 → NP_593173.2  histone acetyltransferase Hat1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593173.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13922, Q9UTM7
      Conserved Domains (2) summary
      cd04301
      Location:171 → 223
      NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
      pfam10394
      Location:7 → 149
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
    Nucleotide Protein
    Heading Accession and Version

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