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    ada2 SAGA complex subunit Ada2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539174, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ada2
    Official Full Name
    SAGA complex subunit Ada2
    Primary source
    PomBase:SPCC24B10.08c
    Locus tag
    SPOM_SPCC24B10.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ada2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (915040..916698, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase (AGC family) Gad8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SAGA histone acetyltransferase module targets SMC5/6 to specific genes. Mahrik L, et al. Epigenetics Chromatin, 2023 Feb 16. PMID 36793083, Free PMC Article
    2. Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26. Hirota K, et al. Mol Biol Cell, 2008 Mar. PMID 18199689, Free PMC Article
    3. Nucleosome eviction in mitosis assists condensin loading and chromosome condensation. Toselli-Mollereau E, et al. EMBO J, 2016 Jul 15. PMID 27266525, Free PMC Article
    4. The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast. Takahashi H, et al. J Biol Chem, 2012 Nov 2. PMID 22992726, Free PMC Article
    5. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. Bao K, et al. Genes Dev, 2019 Jan 1. PMID 30573453, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SAGA-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SAGA complex subunit Ada2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      915040..916698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023002.3 → NP_588011.1  SAGA complex subunit Ada2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588011.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7J7
      Conserved Domains (4) summary
      COG5114
      Location:1 → 437
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      cd02335
      Location:6 → 54
      ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:65 → 108
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam04433
      Location:357 → 433
      SWIRM; SWIRM domain
    Nucleotide Protein
    Heading Accession and Version

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