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    RRB1 ribosome biosynthesis protein RRB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855161, updated on 17-May-2024

    Summary

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    Gene symbol
    RRB1
    Gene description
    ribosome biosynthesis protein RRB1
    Primary source
    FungiDB:YMR131C
    Locus tag
    YMR131C
    See related
    SGD:S000004738; AllianceGenome:SGD:S000004738; VEuPathDB:YMR131C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in ribosome biogenesis. Located in nucleolus. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRB1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (533163..534698, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pom152p Neighboring gene Dpi35p Neighboring gene Jlp2p Neighboring gene Rec114p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rrb1p, a yeast nuclear WD-repeat protein involved in the regulation of ribosome biosynthesis. Iouk TL, et al. Mol Cell Biol, 2001 Feb. PMID 11158312, Free PMC Article
    2. Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability. Killian A, et al. Oncogene, 2004 Nov 11. PMID 15467761
    3. Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones. Pausch P, et al. Nat Commun, 2015 Jun 26. PMID 26112308, Free PMC Article
    4. A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly. Schaper S, et al. Curr Biol, 2001 Nov 27. PMID 11728313
    5. Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis. Pillet B, et al. Elife, 2022 Mar 31. PMID 35357307, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome biosynthesis protein RRB1
    NP_013850.1
    • Specific assembly chaperone for ribosomal protein Rpl3p; co-translationally associates with nascent Rpl3p, preventing aggregation, and facilitating nuclear import; required for biogenesis of preribosomal particles; essential gene; contains five WD-repeat motifs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      533163..534698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182632.1 → NP_013850.1  TPA: ribosome biosynthesis protein RRB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZV4, Q04225
      UniProtKB/TrEMBL
      A0A8H4F9I0, A6ZMJ1, C8ZEY6
      Conserved Domains (3) summary
      sd00039
      Location:276 → 317
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:108 → 175
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:264 → 448
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04225.1

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