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    RTG2 Rtg2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852640, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RTG2
    Official Full Name
    Rtg2p
    Primary source
    SGD:S000003221
    Locus tag
    YGL252C
    See related
    AllianceGenome:SGD:S000003221; FungiDB:YGL252C; VEuPathDB:YGL252C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoprotein binding activity. Involved in several processes, including maintenance of DNA trinucleotide repeats; mitochondria-nucleus signaling pathway; and regulation of transcription by RNA polymerase II. Located in cytoplasm and transcriptionally active chromatin. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RTG2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (25718..27484, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Fzf1p Neighboring gene hexokinase 2 Neighboring gene DNA helicase Neighboring gene Rmr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional mapping of Rtg2p determinants involved in retrograde signaling and aging of Saccharomyces cerevisiae. Rios-Anjos RM, et al. PLoS One, 2017. PMID 28472157, Free PMC Article
    2. Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiae. Bhattacharyya S, et al. Genetics, 2002 Oct. PMID 12399373, Free PMC Article
    3. Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies. Plocek V, et al. Int J Mol Sci, 2021 May 25. PMID 34070491, Free PMC Article
    4. Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Hog1 Activation Which Requires RTG2 in Yeast. Guaragnella N, et al. Oxid Med Cell Longev, 2019. PMID 30931079, Free PMC Article
    5. RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae. Torelli NQ, et al. Free Radic Biol Med, 2015 Apr. PMID 25578655

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. found that most of the residues involved in retrograde signaling surround the ATP-binding loops, and that Rtg2p N-terminus is divided in three regions whose mutants have different aging phenotypes
      Title: Structural and functional mapping of Rtg2p determinants involved in retrograde signaling and aging of Saccharomyces cerevisiae.
    2. RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae.
      Title: RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae.
    3. All four Rtg2p homologs are functional upon activation of retrograde signaling.
      Title: Characterization of fungal RTG2 genes in retrograde signaling of Saccharomyces cerevisiae.
    4. Data suggest that dynamic association between Rtg2p and Mks1p in high molecular weight complexes provides a means to regulate the RTG pathway.
      Title: Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of DNA trinucleotide repeats IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondria-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrogen catabolite regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rtg2p
    NP_011262.1
    • Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      25718..27484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181118.1 → NP_011262.1  TPA: Rtg2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011262.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV83, P32608
      UniProtKB/TrEMBL
      A6ZTT9, B3LHU4, B5VI91, C7GNZ8, C8Z806, G2WDK8, N1P3B8
      Conserved Domains (1) summary
      COG0248
      Location:15 → 561
      GppA; Exopolyphosphatase/pppGpp-phosphohydrolase [Nucleotide transport and metabolism, Signal transduction mechanisms, Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32608.2

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