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    UTH1 SUN family protein UTH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853916, updated on 7-Jul-2024

    Summary

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    Gene symbol
    UTH1
    Gene description
    SUN family protein UTH1
    Primary source
    FungiDB:YKR042W
    Locus tag
    YKR042W
    See related
    SGD:S000001750; AllianceGenome:SGD:S000001750; VEuPathDB:YKR042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydrolase activity, acting on glycosyl bonds. Involved in autophagy of mitochondrion and fungal-type cell wall biogenesis. Is extrinsic component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UTH1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (519527..520624)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene sedoheptulose-bisphosphatase Neighboring gene Uip5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. Weng Y, et al. Bioorg Med Chem, 2010 Feb. PMID 20093034
    2. The SUN41 and SUN42 genes are essential for cell separation in Candida albicans. Firon A, et al. Mol Microbiol, 2007 Dec. PMID 18001349
    3. Evaluation of the roles of apoptosis, autophagy, and mitophagy in the loss of plating efficiency induced by Bax expression in yeast. Kissová I, et al. J Biol Chem, 2006 Nov 24. PMID 16990272
    4. Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death. Camougrand N, et al. FEMS Yeast Res, 2004 Nov. PMID 15489196
    5. Uth1p is involved in the autophagic degradation of mitochondria. Kissová I, et al. J Biol Chem, 2004 Sep 10. PMID 15247238

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
      Title: Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
    2. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
      Title: SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
    3. re-evaluation of its mitochondrial localization revealed that Uth1 is a protein of the inner mitochondrial membrane that is targeted by a cleavable N-terminal pre-sequence
      Title: Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy.
    4. UTH1 is a yeast aging gene that has been identified on the basis of stress resistance and longer life span of mutants.
      Title: Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in division septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUN family protein UTH1
    NP_012968.4
    • Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      519527..520624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179832.3 → NP_012968.4  TPA: SUN family protein UTH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012968.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXA4, P36135
      UniProtKB/TrEMBL
      A0A8H4BZ52, G2WI71, N1P0X3
      Conserved Domains (1) summary
      pfam03856
      Location:111 → 352
      SUN; Beta-glucosidase (SUN family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36135.2

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