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    pcm1 mRNA 5'-cap (guanine-N7-)-methyltransferase Pcm1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539280, updated on 22-Jun-2024

    Summary

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    Gene symbol
    pcm1
    Gene description
    mRNA 5'-cap (guanine-N7-)-methyltransferase Pcm1
    Locus tag
    SPOM_SPCC330.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPCC330.10
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    Genomic context

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    See pcm1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (129693..131013)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase Alg11 Neighboring gene ncRNA Neighboring gene rRNA processing protein Enp2 Neighboring gene ncRNA Neighboring gene BTB/POZ family ubiquitin-type ligase substrate adaptor Btb1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recruitment of P-TEFb (Cdk9-Pch1) to chromatin by the cap-methyl transferase Pcm1 in fission yeast. Guiguen A, et al. EMBO J, 2007 Mar 21. PMID 17332744, Free PMC Article
    2. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Pei Y, et al. Mol Cell Biol, 2006 Feb. PMID 16428435, Free PMC Article
    3. Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. Saha N, et al. J Biol Chem, 1999 Jun 4. PMID 10347220
    4. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Viladevall L, et al. Mol Cell, 2009 Mar 27. PMID 19328067, Free PMC Article
    5. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. St Amour CV, et al. Mol Cell Biol, 2012 Jul. PMID 22508988, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of P-TEFb-cap methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA 5'-cap (guanine-N7-)-methyltransferase Pcm1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      129693..131013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355861.2 → NP_001342758.1  mRNA 5'-cap (guanine-N7-)-methyltransferase Pcm1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74880
      Conserved Domains (1) summary
      pfam03291
      Location:52 → 358
      Pox_MCEL; mRNA capping enzyme
    Nucleotide Protein
    Heading Accession and Version

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