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    HIR3 Hir3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853605, updated on 17-May-2024

    Summary

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    Gene symbol
    HIR3
    Gene description
    Hir3p
    Primary source
    FungiDB:YJR140C
    Locus tag
    YJR140C
    See related
    SGD:S000003901; AllianceGenome:SGD:S000003901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HPC1
    Summary
    Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in several processes, including DNA replication-independent chromatin assembly; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; and transcription elongation from RNA polymerase II promoter. Located in nucleus. Part of HIR complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HIR3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (690750..695696, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein IML1 Neighboring gene homoserine dehydrogenase Neighboring gene putative polyadenylation protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling the regulatory network of histone acetylation in Saccharomyces cerevisiae. Pham H, et al. Mol Syst Biol, 2007. PMID 18091724, Free PMC Article
    2. Host genes that affect the target-site distribution of the yeast retrotransposon Ty1. Huang H, et al. Genetics, 1999 Apr. PMID 10101165, Free PMC Article
    3. The HIR4-1 mutation defines a new class of histone regulatory genes in Saccharomyces cerevisiae. Spector MS, et al. Genetics, 1993 Sep. PMID 8224824, Free PMC Article
    4. The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Prochasson P, et al. Genes Dev, 2005 Nov 1. PMID 16264190, Free PMC Article
    5. Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Qian Z, et al. Mol Cell Biol, 1998 Aug. PMID 9671488, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HIR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HIR complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hir3p
    NP_012674.1
    • Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      690750..695696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181798.1 → NP_012674.1  TPA: Hir3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012674.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV9, P47171
      UniProtKB/TrEMBL
      A0A8H4C0F5, A6ZQ96, N1P3Q9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47171.1

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