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    sst2 AMSH-like ubiquitin-specific protease [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542606, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sst2
    Official Full Name
    AMSH-like ubiquitin-specific protease
    Primary source
    PomBase:SPAC19B12.10
    Locus tag
    SPOM_SPAC19B12.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sst2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (4901611..4904311)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Atg8 deconjugator Atg4 Neighboring gene signal recognition particle subunit Srp14 Neighboring gene ncRNA Neighboring gene zinc finger ribosome biogenesis protein Neighboring gene ncRNA Neighboring gene SMN complex subunit Yip11/Gem2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the Thr316Ala mutant of a yeast JAMM deubiquitinase: implication of active-site loop dynamics in catalysis. Shrestha R, et al. Acta Crystallogr F Struct Biol Commun, 2021 Jun 1. PMID 34100774, Free PMC Article
    2. Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase. Bueno AN, et al. Biochemistry, 2015 Oct 6. PMID 26368668, Free PMC Article
    3. Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product. Shrestha RK, et al. Biochemistry, 2014 May 20. PMID 24787148, Free PMC Article
    4. A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival. Beckley JR, et al. Mol Cell Proteomics, 2015 Dec. PMID 26412298, Free PMC Article
    5. Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. Onishi M, et al. Biosci Biotechnol Biochem, 2003 Aug. PMID 12951513

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.
      Title: Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.
    2. AMSH associates with endosomes, inhibition would be relieved because of ubiquitin binding domains present on its endosomal binding partners that would shift the balance toward better recognition of polyubiquitin chains via the avidity effect.
      Title: Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    NOT enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity HDA PubMed 
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal-dependent deubiquitinase activity HMP PubMed 
    enables metal-dependent deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMSH-like ubiquitin-specific protease
    NP_001342969.1
    • human AMSH/STAMBP protein homolog, ubiquitin specific-protease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4901611..4904311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356187.2 → NP_001342969.1  AMSH-like ubiquitin-specific protease [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P371
      Conserved Domains (2) summary
      cd08066
      Location:260 → 433
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:26 → 111
      USP8_dimer; USP8 dimerisation domain
    Nucleotide Protein
    Heading Accession and Version

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