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    rec12 DNA topoisomerase type II (DSB-forming) Rec12/Spo11 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542150, updated on 18-Sep-2024

    Summary

    Official Symbol
    rec12
    Official Full Name
    DNA topoisomerase type II (DSB-forming) Rec12/Spo11
    Primary source
    PomBase:SPAC17A5.11
    Locus tag
    SPOM_SPAC17A5.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    spo11
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    Genomic context

    See rec12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (1772925..1774203)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein hua1 Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UBA/TPR/DNAJ domain protein Ucp7 Neighboring gene GTP cyclohydrolase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
     
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
     
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in homologous chromosome orientation in meiotic metaphase I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus HDA PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA topoisomerase type II (DSB-forming) Rec12/Spo11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1772925..1774203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018912.1NP_593479.1  DNA topoisomerase type II (DSB-forming) Rec12/Spo11 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593479.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40384
      Conserved Domains (3) summary
      cd00223
      Location:173328
      TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
      COG1697
      Location:1343
      Spo11; DNA topoisomerase VI, subunit A [Replication, recombination and repair]
      pfam04406
      Location:69130
      TP6A_N; Type IIB DNA topoisomerase