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    SWT1 mRNA-processing endoribonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854337, updated on 17-May-2024

    Summary

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    Gene symbol
    SWT1
    Gene description
    mRNA-processing endoribonuclease
    Primary source
    FungiDB:YOR166C
    Locus tag
    YOR166C
    See related
    SGD:S000005692; AllianceGenome:SGD:S000005692; VEuPathDB:YOR166C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endoribonuclease activity. Involved in nuclear mRNA surveillance of mRNP export and transcription elongation from RNA polymerase II promoter. Located in cytoplasm and nucleus. Orthologous to human SWT1 (SWT1 RNA endoribonuclease homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SWT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (647126..648502, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Get4p Neighboring gene dynamin-like GTPase SEY1 Neighboring gene ribosomal 40S subunit protein S28A Neighboring gene glutamine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S. cerevisiae RNA endonuclease Swt1. Peng S, et al. Biochem Biophys Res Commun, 2014 Oct 31. PMID 25450355
    2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
    3. Swt1, a novel yeast protein, functions in transcription. Röther S, et al. J Biol Chem, 2006 Dec 1. PMID 17030511
    4. Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae. Nasution O, et al. Environ Microbiol, 2015 Aug. PMID 25297926
    5. An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. Skruzný M, et al. PLoS Biol, 2009 Jan 6. PMID 19127978, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swt1 functions in gene expression in conjunction with the TREX complex
      Title: Swt1, a novel yeast protein, functions in transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear mRNA surveillance of mRNP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA-processing endoribonuclease
    NP_014809.3
    • RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      647126..648502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183585.3 → NP_014809.3  TPA: mRNA-processing endoribonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014809.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2M4, Q12104
      UniProtKB/TrEMBL
      A0A8H4BV84, A6ZP11, B3LJJ9, B5VS53, C7GN58, C8ZGS7, N1NWP8
      Conserved Domains (1) summary
      cd18727
      Location:133 → 280
      PIN_Swt1-like; VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12104.1

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