TEF4 translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TEF4
Gene description: translation elongation factor EF1B gamma
Primary source: FungiDB:YKL081W
Locus tag: YKL081W
See related: SGD:S000001564; AllianceGenome:SGD:S000001564; VEuPathDB:YKL081W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: EFC1
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in translational elongation. Located in cytoplasmic stress granule. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TEF4 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 2

Sequence:: Chromosome: XI; NC_001143.9 (282891..284455)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the two nonessential genes encoding eEF1Bgamma (TEF3 & TEF4)has no dramatic effects on total protein synthesis or translational fidelity. Instead, loss of each gene gives resistance to oxidative stress.
Title: The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-61c1 (e-PCR)
- UniSTS:258034

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in ribosome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: translation elongation factor EF1B gamma

NP_012842.1

Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

282891..284455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179647.1 → NP_012842.1 TPA: translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012842.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXK6, P36008

UniProtKB/TrEMBL

B3LR10, C8ZC92, N1P2A1

Conserved Domains (3) summary

cd03181
Location:89 → 211

GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins

cd03044
Location:4 → 72

GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...

pfam00647
Location:253 → 356

EF1G; Elongation factor 1 gamma, conserved domain