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    sak1 DNA-binding transcription factor Sak1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543421, updated on 22-Jun-2024

    Summary

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    Gene symbol
    sak1
    Gene description
    DNA-binding transcription factor Sak1
    Locus tag
    SPOM_SPAC3G9.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC3G9.14
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    Genomic context

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    See sak1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3146948..3149719, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TRAPP complex subunit Bet5 Neighboring gene ncRNA Neighboring gene rRNA processing protein Fcf2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tryptophan--tRNA (Trp) ligase Msw1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle. Wu SY, et al. Mol Cell Biol, 1995 Mar. PMID 7862141, Free PMC Article
    2. A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression. Garg A, et al. Nucleic Acids Res, 2015 Aug 18. PMID 25908789, Free PMC Article
    3. An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation. Yuasa T, et al. Genes Cells, 2004 Nov. PMID 15507118
    4. Predicting the fission yeast protein interaction network. Pancaldi V, et al. G3 (Bethesda), 2012 Apr. PMID 22540037, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study found that Sak1 is intimately involved in mitotic gene control and may be the ultimate transcriptional activator of most or perhaps all of the mitotic genes.
      Title: A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcription factor Sak1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3146948..3149719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019499.3 → NP_594086.1  DNA-binding transcription factor Sak1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594086.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42876, P48383
      Conserved Domains (1) summary
      pfam02257
      Location:98 → 174
      RFX_DNA_binding; RFX DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials