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    trx2 thioredoxin Trx2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539898, updated on 22-Jun-2024

    Summary

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    Gene symbol
    trx2
    Gene description
    thioredoxin Trx2
    Locus tag
    SPOM_SPBC12D12.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPBC12D12.07c
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    Genomic context

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    See trx2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2317361..2318530, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene calcium-binding subfamily carrier protein Neighboring gene DNA polymerase zeta Rev7 Neighboring gene ncRNA Neighboring gene cyclin CycC-like Srb mediator subunit Srb11 Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thiol-independent action of mitochondrial thioredoxin to support the urea cycle of arginine biosynthesis in Schizosaccharomyces pombe. Song JY, et al. Eukaryot Cell, 2008 Dec. PMID 18849471, Free PMC Article
    2. Characterization and regulation of a second gene encoding thioredoxin from the fission yeast. Lee YJ, et al. Biochim Biophys Acta, 2002 May 3. PMID 12020831
    3. Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast. Lee SY, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18162174
    4. Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast. Song JY, et al. Eukaryot Cell, 2006 Nov. PMID 16950927, Free PMC Article
    5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trx2 protects mitochondrial components against thiol-oxidative damage and supports urea cycle.
      Title: Thiol-independent action of mitochondrial thioredoxin to support the urea cycle of arginine biosynthesis in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular detoxification NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin Trx2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2317361..2318530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021863.3 → NP_595954.2  thioredoxin Trx2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595954.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94504
      Conserved Domains (1) summary
      cd02947
      Location:39 → 122
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version

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