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    PAC10 tubulin-binding prefolding complex subunit PAC10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852969, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PAC10
    Official Full Name
    tubulin-binding prefolding complex subunit PAC10
    Primary source
    SGD:S000003310
    Locus tag
    YGR078C
    See related
    AllianceGenome:SGD:S000003310; FungiDB:YGR078C; VEuPathDB:YGR078C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GIM2; PFD3; RKS2
    Summary
    Enables tubulin binding activity. Involved in tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Used to study cancer. Orthologous to human VBP1 (VHL binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PAC10 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (639772..640371, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL25 Neighboring gene Pex8p Neighboring gene uncharacterized protein Neighboring gene Twf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protection from free beta-tubulin by the beta-tubulin binding protein Rbl2p. Abruzzi KC, et al. Mol Cell Biol, 2002 Jan. PMID 11739729, Free PMC Article
    2. A novel step in beta-tubulin folding is important for heterodimer formation in Saccharomyces cerevisiae. Lacefield S, et al. Genetics, 2003 Oct. PMID 14573467, Free PMC Article
    3. Consequences of defective tubulin folding on heterodimer levels, mitosis and spindle morphology in Saccharomyces cerevisiae. Lacefield S, et al. Genetics, 2006 Jun. PMID 16582437, Free PMC Article
    4. Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. Siegers K, et al. EMBO J, 1999 Jan 4. PMID 9878052, Free PMC Article
    5. Sse1, Hsp110 chaperone of yeast, controls the cellular fate during endoplasmic reticulum stress. Jha MP, et al. G3 (Bethesda), 2024 Jun 5. PMID 38577891, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin-binding prefolding complex subunit PAC10
    NP_011592.3
    • Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      639772..640371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181207.3 → NP_011592.3  TPA: tubulin-binding prefolding complex subunit PAC10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011592.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUL0, P48363
      UniProtKB/TrEMBL
      A6ZV60, B3LIE8, B5VJ22, C7GXQ7, C8Z8X2, G2WEG2, N1P270
      Conserved Domains (1) summary
      pfam02996
      Location:48 → 177
      Prefoldin; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48363.1

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