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    YPP1 Ypp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853112, updated on 7-Jul-2024

    Summary

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    Gene symbol
    YPP1
    Gene description
    Ypp1p
    Primary source
    FungiDB:YGR198W
    Locus tag
    YGR198W
    See related
    SGD:S000003430; AllianceGenome:SGD:S000003430; VEuPathDB:YGR198W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including protein localization to plasma membrane; protein targeting to vacuole; and response to pheromone. Located in several cellular components, including actin cortical patch; cytosol; and endosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YPP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (894693..897146)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Fyv8p Neighboring gene Sng1p Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 Neighboring gene Elongator subunit ELP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Wu X, et al. Dev Cell, 2014 Jan 13. PMID 24360784, Free PMC Article
    2. Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Zhai C, et al. Biochem J, 2008 Nov 1. PMID 18601652
    3. Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. Baird D, et al. J Cell Biol, 2008 Dec 15. PMID 19075114, Free PMC Article
    4. The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Rodriguez-Peña JM, et al. Yeast, 1998 Jun 30. PMID 9818723
    5. A heat-sensitive Osh protein controls PI4P polarity. Omnus DJ, et al. BMC Biol, 2020 Mar 13. PMID 32169085, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ypp1 and Efr3 are required for the formation and architecture of Stt4 PIK patches and ultimately plasma membrane-based PtdIns4P signaling.
      Title: Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.
    2. a role for Ypp1 in Stt4-dependent events at the plasma membrane, as opposed to a general role in overall metabolism of phosphatidylinositol 4-phosphate.
      Title: Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane.
    3. YPP1 mediates the trafficking of A30P to the vacuole via the endocytic pathway.
      Title: YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ypp1p
    NP_011714.3
    • Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      894693..897146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181327.3 → NP_011714.3  TPA: Ypp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011714.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUY0, P46951
      UniProtKB/TrEMBL
      A0A8H4FBR8, B5VJE1, C8Z991, N1P9Y1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46951.1

    Gene LinkOut

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