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    ADH6 NADP-dependent alcohol dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855368, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ADH6
    Gene description
    NADP-dependent alcohol dehydrogenase
    Primary source
    FungiDB:YMR318C
    Locus tag
    YMR318C
    See related
    SGD:S000004937; AllianceGenome:SGD:S000004937; VEuPathDB:YMR318C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADHVI
    Summary
    Enables alcohol dehydrogenase (NADP+) activity; hydroxymethylfurfural reductase (NADH) activity; and hydroxymethylfurfural reductase (NADPH) activity. Involved in alcohol metabolic process and furaldehyde metabolic process. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADH6 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (911061..912143, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Dia1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fet4p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electrochemical probing of in vivo 5-hydroxymethyl furfural reduction in Saccharomyces cerevisiae. Kostesha NV, et al. Anal Chem, 2009 Dec 15. PMID 19925001
    2. Apo and Holo structures of an NADPH-dependent cinnamyl alcohol dehydrogenase from Saccharomyces cerevisiae. Valencia E, et al. J Mol Biol, 2004 Aug 20. PMID 15289102
    3. Properties and functional significance of Saccharomyces cerevisiae ADHVI. Larroy C, et al. Chem Biol Interact, 2003 Feb 1. PMID 12604208
    4. Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene product as a broad specificity NADPH-dependent alcohol dehydrogenase: relevance in aldehyde reduction. Larroy C, et al. Biochem J, 2002 Jan 1. PMID 11742541, Free PMC Article
    5. Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. Buchhaupt M, et al. Appl Microbiol Biotechnol, 2012 Jan. PMID 21789493

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-methylbutanal reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cinnamyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylfurfural reductase (NADH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydroxymethylfurfural reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alcohol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alcohol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular aldehyde metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in furaldehyde metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent alcohol dehydrogenase
    NP_014051.3
    • NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      911061..912143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182831.3 → NP_014051.3  TPA: NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014051.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0E6, Q04894
      UniProtKB/TrEMBL
      A0A7I9FXN4, A6ZN36, B3LMK7, B5VQ85, C7GPU5, C8ZFJ1, G2WL30, N1NYX0
      Conserved Domains (1) summary
      cd05283
      Location:8 → 352
      CAD1; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04894.1

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