CDC40 Cdc40p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: CDC40
Gene description: Cdc40p
Primary source: FungiDB:YDR364C
Locus tag: YDR364C
See related: SGD:S000002772; AllianceGenome:SGD:S000002772; VEuPathDB:YDR364C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PRP17; SLT15; SLU4
Summary: Contributes to second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step; mRNA 3'-splice site recognition; and mRNA branch site recognition. Located in nuclear periphery. Part of spliceosomal complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human CDC40 (cell division cycle 40). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data show that Prp17 interacts with U2, U5 and U6 snRNPs (small nuclear ribonucleoproteins) but it is not a core component of any one snRNP.
Title: The splicing factor Prp17 interacts with the U2, U5 and U6 snRNPs and associates with the spliceosome pre- and post-catalysis.
Mutants are hydroxyurea- and methylmethane sulfonate-sensitive due to their S-phase entry defect.
Title: A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.
role in splicing of subsets of introns
Title: Genome-wide analysis of pre-mRNA splicing: intron features govern the requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to second spliceosomal transesterification activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in generation of catalytic spliceosome for second transesterification step	IGI Inferred from Genetic Interaction more info	PubMed
involved_in generation of catalytic spliceosome for second transesterification step	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA 3'-splice site recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA branch site recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

NP_010652.3

Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40

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