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    MIF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853773, updated on 22-Aug-2024

    Summary

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    Official Symbol
    MIF2
    Primary source
    FungiDB:YKL089W
    Locus tag
    YKL089W
    See related
    SGD:S000001572; AllianceGenome:SGD:S000001572; VEuPathDB:YKL089W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables centromeric DNA binding activity. Involved in chromosome segregation; kinetochore assembly; and mitotic spindle organization. Located in condensed chromosome, centromeric region. Human ortholog(s) of this gene implicated in CREST syndrome and liver cirrhosis. Orthologous to human CENPC (centromere protein C). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MIF2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (273394..275043)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein Neighboring gene Cue2p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3 Neighboring gene cytochrome c1 heme lyase CYT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. Cohen RL, et al. Mol Biol Cell, 2008 Oct. PMID 18701705, Free PMC Article
    2. MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. Brown MT, et al. J Cell Biol, 1993 Oct. PMID 8408221, Free PMC Article
    3. Sequence similarities between the yeast chromosome segregation protein Mif2 and the mammalian centromere protein CENP-C. Brown MT. Gene, 1995 Jul 4. PMID 7628703
    4. Isolation of two genes that affect mitotic chromosome transmission in S. cerevisiae. Meeks-Wagner D, et al. Cell, 1986 Jan 17. PMID 3510080
    5. Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres. Xiao H, et al. Genes Dev, 2017 Oct 1. PMID 29074736, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast.
      Title: Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast.
    2. Mif2p dimer seems to be part of an enhanceosome-like structure that nucleates kinetochore assembly in budding yeast
      Title: Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables centromeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables centromeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables centromeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mif2p
    NP_012834.1
    • Centromeric CDEIII region binding protein; nucleates kinetochore assembly; required for the structural integrity of elongating spindles; copurifies with subunits of the MIND complex and centromeric nucleosome components (Cse4p and histones H2A, H2B, and H4); phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; localizes to the kinetochore

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      273394..275043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179655.1 → NP_012834.1  TPA: Mif2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXJ9, P35201
      UniProtKB/TrEMBL
      A6ZZM8, C7GVM1, G2WHU4, N1P063
      Conserved Domains (2) summary
      pfam11699
      Location:439 → 526
      CENP-C_C; Mif2/CENP-C like
      pfam15624
      Location:3 → 35
      Mif2_N; Kinetochore CENP-C fungal homolog, Mif2, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35201.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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