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    TFC3 transcription factor TFIIIC subunit TFC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851262, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TFC3
    Official Full Name
    transcription factor TFIIIC subunit TFC3
    Primary source
    SGD:S000000001
    Locus tag
    YAL001C
    See related
    AllianceGenome:SGD:S000000001; FungiDB:YAL001C; VEuPathDB:YAL001C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN24; TSV115
    Summary
    Contributes to DNA binding activity, bending; RNA polymerase III type 1 promoter sequence-specific DNA binding activity; and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III and protein localization to chromatin. Located in mitochondrion. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TFC3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_001133.9 (147594..151166, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene translation elongation factor 1 subunit beta Neighboring gene ncRNA Neighboring gene CORVET complex membrane-binding subunit VPS8 Neighboring gene FG-nucleoporin NUP60 Neighboring gene Erp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TFIIIC binding sites function as both heterochromatin barriers and chromatin insulators in Saccharomyces cerevisiae. Simms TA, et al. Eukaryot Cell, 2008 Dec. PMID 18849469, Free PMC Article
    2. Genetic analysis of Saccharomyces cerevisiae chromosome I: on the role of mutagen specificity in delimiting the set of genes identifiable using temperature-sensitive-lethal mutations. Harris SD, et al. Genetics, 1991 Feb. PMID 2004703, Free PMC Article
    3. TFC3: gene encoding the B-block binding subunit of the yeast transcription factor IIIC. Lefebvre O, et al. Proc Natl Acad Sci U S A, 1992 Nov 1. PMID 1279682, Free PMC Article
    4. Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex. Kleinschmidt RA, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21536876, Free PMC Article
    5. Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Arrebola R, et al. Mol Cell Biol, 1998 Jan. PMID 9418847, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tau55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities, and provide a small set of regulated phosphosite targets in vivo.
      Title: Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC.
    2. the TFC6 promoter is directly regulated by the TF(III)C complex, a demonstration of an RNA polymerase II promoter being directly responsive to a core Pol III transcription factor complex.
      Title: Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex.
    3. Partially assembled Pol III complexes containing only the TFIIIC exhibit chromatin boundary functions both as heterochromatin barriers and as insulators to gene activation.
      Title: TFIIIC binding sites function as both heterochromatin barriers and chromatin insulators in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5S class rRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 5S class rRNA transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase III promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIIC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor TFIIIC subunit TFC3
    NP_009400.1
    • Subunit of RNA polymerase III transcription initiation factor complex; part of TauB domain of TFIIIC that binds DNA at BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); colocalizes with condensin at pol III genes and several ETC (extra TFIIIC) sites; may have a role in recruiting or stabilizing Scc2/4 and condensin on chromosomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      147594..151166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178148.1 → NP_009400.1  TPA: transcription factor TFIIIC subunit TFC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPL5, P34111
      UniProtKB/TrEMBL
      B3LUU0, C8Z3H7, N1P935
      Conserved Domains (2) summary
      cd16169
      Location:549 → 639
      Tau138_eWH; extended winged-helix domain of tau138 and related proteins
      pfam04182
      Location:107 → 175
      B-block_TFIIIC; B-block binding subunit of TFIIIC
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34111.1

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