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    SMD2 mRNA splicing protein SMD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850981, updated on 17-May-2024

    Summary

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    Gene symbol
    SMD2
    Gene description
    mRNA splicing protein SMD2
    Primary source
    FungiDB:YLR275W
    Locus tag
    YLR275W
    See related
    SGD:S000004265; AllianceGenome:SGD:S000004265; VEuPathDB:YLR275W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Part of U2-type prespliceosome and spliceosomal snRNP complex. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SMD2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (694378..694800)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator PIG1 Neighboring gene MCM DNA helicase complex subunit MCM5 Neighboring gene ATP-dependent DNA/RNA helicase Neighboring gene cleavage polyadenylation factor subunit YSH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. Yang Y, et al. PLoS Genet, 2013. PMID 23966873, Free PMC Article
    2. Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. Caspary F, et al. EMBO J, 1999 Jun 15. PMID 10369685, Free PMC Article
    3. Functional characterization of nuclear localization signals in yeast Sm proteins. Bordonné R. Mol Cell Biol, 2000 Nov. PMID 11027265, Free PMC Article
    4. Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain. Walke S, et al. J Mol Biol, 2001 Apr 20. PMID 11302706
    5. Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Neubauer G, et al. Proc Natl Acad Sci U S A, 1997 Jan 21. PMID 9012791, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small nuclear ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein SMD2
    NP_013377.1
    • Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      694378..694800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182162.1 → NP_013377.1  TPA: mRNA splicing protein SMD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYS2, Q06217
      UniProtKB/TrEMBL
      A7A1F9, B3RHF7, C8ZDN9, G2WJA1
      Conserved Domains (1) summary
      cd01720
      Location:27 → 108
      Sm_D2; Sm protein D2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCM_Q.1
    3JCM_U.1
    5GMK_e.1
    5GMK_g.1
    5WSG_W.1
    5WSG_g.1
    5Y88_g.1
    5Y88_n.1
    5YLZ_g.1
    5YLZ_n.1
    5ZWM_R.1
    5ZWM_c.1
    5ZWM_n.1
    5ZWN_c.1
    5ZWO_R.1
    5ZWO_c.1
    5ZWO_n.1
    6BK8_a.1
    6BK8_q.1
    6EXN_j.1
    6EXN_m.1
    6J6G_e.1
    6J6G_g.1
    6J6H_e.1
    6J6H_g.1
    6J6N_e.1
    6J6N_g.1
    6J6Q_e.1
    6J6Q_g.1
    6N7P_M.1
    6N7R_M.1
    6N7X_M.1
    Q06217.2

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