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    MCP1 Mcp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854403, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MCP1
    Gene description
    Mcp1p
    Primary source
    FungiDB:YOR228C
    Locus tag
    YOR228C
    See related
    SGD:S000005754; AllianceGenome:SGD:S000005754; VEuPathDB:YOR228C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in lipid homeostasis and mitochondrion organization. Located in mitochondrial outer membrane. Is integral component of mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MCP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (766869..767777, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative iron-binding protein ISU2 Neighboring gene Her1p Neighboring gene transcriptional modulator Neighboring gene transcriptional modulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis. English AM, et al. J Cell Biol, 2020 Dec 7. PMID 33090183, Free PMC Article
    2. Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites. John Peter AT, et al. J Cell Biol, 2017 Oct 2. PMID 28864540, Free PMC Article
    3. The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus. Kolakowski D, et al. Int J Mol Sci, 2021 Nov 12. PMID 34830155, Free PMC Article
    4. A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13. Dziurdzik SK, et al. Hum Mol Genet, 2020 Mar 13. PMID 31943017, Free PMC Article
    5. Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites. Bean BDM, et al. J Cell Biol, 2018 Oct 1. PMID 30018089, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mcp1p
    NP_014871.3
    • Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      766869..767777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183647.3 → NP_014871.3  TPA: Mcp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014871.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2T2, Q12106
      UniProtKB/TrEMBL
      A6ZP69, B3LJQ0, C7GWF6, C8ZGY1, N1NYP6
      Conserved Domains (1) summary
      pfam07950
      Location:182 → 278
      DUF1691; Protein of unknown function (DUF1691)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12106.1

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