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    SLM4 Slm4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852369, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLM4
    Official Full Name
    Slm4p
    Primary source
    SGD:S000000281
    Locus tag
    YBR077C
    See related
    AllianceGenome:SGD:S000000281; FungiDB:YBR077C; VEuPathDB:YBR077C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EGO3; GSE1; NIR1
    Summary
    Involved in lysosomal microautophagy and signal transduction. Located in fungal-type vacuole membrane and late endosome membrane. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SLM4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (391805..392293, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Pff1p Neighboring gene Ecm8p Neighboring gene Ecm33p Neighboring gene translation initiation factor eIF3 core subunit a

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Huang J, et al. Proc Natl Acad Sci U S A, 2004 Nov 23. PMID 15539461, Free PMC Article
    2. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Zhang T, et al. Structure, 2012 Dec 5. PMID 23123112
    3. Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals. Kogan K, et al. J Mol Biol, 2010 Sep 17. PMID 20655927
    4. Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases. Zhang T, et al. Sci Adv, 2019 Sep. PMID 31579828, Free PMC Article
    5. Akr1 attenuates methylmercury toxicity through the palmitoylation of Meh1 as a subunit of the yeast EGO complex. Zhang ZT, et al. Biochim Biophys Acta Gen Subj, 2017 Jul. PMID 28315413

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ego2 interacts with Ego1 and Ego3 to form a stable complex, of which all three components are necessary for the vacuolar recruitment of the Gtr1-Gtr2 GTPases and the activation of TORC1 signaling in response to the presence of amino acids.
      Title: Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.
    2. The unique dimer conformation of Ego3 is essential for the integrity and function of the EGO complex in Saccharomyces cerevisiae.
      Title: Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1.
    3. Gtr2 and the EGO fungal proteins (Ego1 and Ego3) complexes orchestrate microautophagy in yeasts.
      Title: The TOR and EGO protein complexes orchestrate microautophagy in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ragulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ragulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ragulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Slm4p
    NP_009633.3
    • Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; essential for integrity and function of EGO; targeted to vacuole via AP-3 pathway; gene exhibits synthetic genetic interaction with MSS4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      391805..392293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178425.3 → NP_009633.3  TPA: Slm4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009633.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ76, P38247
      UniProtKB/TrEMBL
      A6ZL20, B3LN74, C7GQJ0, D3UEH1, G2W982, N1P6J6
      Conserved Domains (1) summary
      pfam16818
      Location:3 → 161
      SLM4; Protein SLM4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38247.1

    Gene LinkOut

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