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    clr2 SHREC complex subunit Clr2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542596, updated on 22-Jun-2024

    Summary

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    Gene symbol
    clr2
    Gene description
    SHREC complex subunit Clr2
    Locus tag
    SPOM_SPAC1B3.17
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC1B3.17
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    Genomic context

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    See clr2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4964493..4966980)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative mitochondrial ribosomal protein subunit S18 Neighboring gene ncRNA Neighboring gene Pig-U family GPI transamidase subunit Neighboring gene ribosome biogenesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe. Steinhauf D, et al. PLoS One, 2014. PMID 24475199, Free PMC Article
    2. Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Thon G, et al. Genetics, 1994 Sep. PMID 8001791, Free PMC Article
    3. SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Job G, et al. Mol Cell, 2016 Apr 21. PMID 27105116, Free PMC Article
    4. Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Ekwall K, et al. Genetics, 1994 Jan. PMID 8138176, Free PMC Article
    5. A novel jmjC domain protein modulates heterochromatization in fission yeast. Ayoub N, et al. Mol Cell Biol, 2003 Jun. PMID 12773576, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clr2 plays a major role in mating-type and rDNA silencing, and has weaker effects on centromeric silencing.
      Title: Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CENP-A containing chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SHREC complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of SHREC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SHREC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mating-type region heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SHREC complex subunit Clr2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4964493..4966980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020230.3 → NP_594802.1  SHREC complex subunit Clr2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594802.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13881
      Conserved Domains (2) summary
      pfam10383
      Location:367 → 486
      Clr2; Transcription-silencing protein Clr2
      pfam16761
      Location:131 → 198
      Clr2_transil; Transcription-silencing protein, cryptic loci regulator Clr2
    Nucleotide Protein
    Heading Accession and Version

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