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    YEF3 translation elongation factor EF-3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850951, updated on 7-Jul-2024

    Summary

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    Gene symbol
    YEF3
    Gene description
    translation elongation factor EF-3
    Primary source
    FungiDB:YLR249W
    Locus tag
    YLR249W
    See related
    SGD:S000004239; AllianceGenome:SGD:S000004239; VEuPathDB:YLR249W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TEF3
    Summary
    Enables ATP hydrolysis activity and translation elongation factor activity. Involved in translational elongation and translational termination. Located in cytoplasmic stress granule and cytosolic ribosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YEF3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (636780..639914)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase IRC20 Neighboring gene serine/threonine protein kinase RCK2 Neighboring gene Ssp120p Neighboring gene ethanol metabolism protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation. Ranjan N, et al. EMBO J, 2021 Mar 15. PMID 33555093, Free PMC Article
    2. Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae. Kasari V, et al. Sci Rep, 2019 Feb 28. PMID 30816176, Free PMC Article
    3. Mutations in the chromodomain-like insertion of translation elongation factor 3 compromise protein synthesis through reduced ATPase activity. Sasikumar AN, et al. J Biol Chem, 2014 Feb 21. PMID 24379402, Free PMC Article
    4. Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP. Kurata S, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534490, Free PMC Article
    5. Domain and nucleotide dependence of the interaction between Saccharomyces cerevisiae translation elongation factors 3 and 1A. Anand M, et al. J Biol Chem, 2006 Oct 27. PMID 16954224

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.
      Title: Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20.
    2. Protein aggregation and the evolution of stress resistance in clinical yeast.
      Title: Protein aggregation and the evolution of stress resistance in clinical yeast.
    3. Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation.
      Title: Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation.
    4. Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.
      Title: Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.
    5. the elongation factor Yef3 was found to interact with mRNA in non-coding regions and in a translation independent manner. These results suggest an additional, non-elongation function for this factor.
      Title: The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner.
    6. Data indicate that the growth defect associated with constitutively active Gcn2 was diminished by eEF3 (YEF3) overexpression.
      Title: Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational termination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation elongation factor EF-3
    NP_013350.1
    • Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; interacts with mRNA independently of translation; involved in frameshifting at stalled ribosomes; YEF3 has a paralog, HEF3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      636780..639914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182136.1 → NP_013350.1  TPA: translation elongation factor EF-3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYP7, O93815, P16521, Q06558
      UniProtKB/TrEMBL
      A0A6A5PU98, A7A1D2, B3RHD4, B5VNG5, C7GQY7, C8ZDL2, G2WJ75, N1NYG5
      Conserved Domains (3) summary
      COG0488
      Location:431 → 986
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      sd00044
      Location:129 → 158
      HEAT; HEAT repeat [structural motif]
      pfam17947
      Location:336 → 411
      4HB; Four helical bundle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16521.4

    Gene LinkOut

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