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    MET22 3'(2'),5'-bisphosphate nucleotidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854090, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MET22
    Official Full Name
    3'(2'),5'-bisphosphate nucleotidase
    Primary source
    SGD:S000005425
    Locus tag
    YOL064C
    See related
    AllianceGenome:SGD:S000005425; FungiDB:YOL064C; VEuPathDB:YOL064C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HAL2
    Summary
    Enables 3'(2'),5'-bisphosphate nucleotidase activity. Involved in several processes, including hyperosmotic salinity response; methionine biosynthetic process; and tRNA decay. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MET22 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (206103..207176, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2 Neighboring gene phosphoinositide 5-phosphatase INP54 Neighboring gene Crt10p Neighboring gene Apm4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nucleotide metabolite controls stress-responsive gene expression and plant development. Chen H, et al. PLoS One, 2011. PMID 22028934, Free PMC Article
    2. Novel 3'-phosphoadenosine-5'-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts. Vaupotic T, et al. Fungal Genet Biol, 2007 Nov. PMID 17420146
    3. Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. York JD, et al. Proc Natl Acad Sci U S A, 1995 May 23. PMID 7761465, Free PMC Article
    4. A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activation. Murguía JR, et al. Science, 1995 Jan 13. PMID 7809627
    5. Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene. Gläser HU, et al. EMBO J, 1993 Aug. PMID 8393782, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data revealed the genes ESP1 and MET22 as two, so far unknown, genetic determinants of resuming proliferation upon exposure to acetic acid.
      Title: Identification of novel genes involved in acetic acid tolerance of Saccharomyces cerevisiae using pooled-segregant RNA sequencing.
    2. Overexpression of HAL2 in bdf1Delta mutant proterin increases gene expression in the iron-acquisition pathway.
      Title: HAL2 overexpression induces iron acquisition in bdf1Δ cells and enhances their salt resistance.
    3. Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
      Title: Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'(2'),5'-bisphosphate nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3'(2'),5'-bisphosphate nucleotidase
    NP_014577.1
    • Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      206103..207176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183319.1 → NP_014577.1  TPA: 3'(2'),5'-bisphosphate nucleotidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W203, P32179, Q6RFY5
      UniProtKB/TrEMBL
      A6ZNE6, B3LIZ6, C7GK31, G2WMH0, N1NWD7
      Conserved Domains (1) summary
      TIGR01330
      Location:2 → 357
      bisphos_HAL2; 3'(2'),5'-bisphosphate nucleotidase, HAL2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32179.1

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