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    GEP5 Gep5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850780, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GEP5
    Official Full Name
    Gep5p
    Primary source
    SGD:S000004081
    Locus tag
    YLR091W
    See related
    AllianceGenome:SGD:S000004081; FungiDB:YLR091W; VEuPathDB:YLR091W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RRG5
    Summary
    Involved in mitochondrial genome maintenance and mitochondrial tRNA 5'-end processing. Located in matrix side of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GEP5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (322297..323178)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene alanine transaminase ALT1 Neighboring gene Xdj1p Neighboring gene sulfate permease Neighboring gene Nyv1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 5' processing of Saccharomyces cerevisiae mitochondrial tRNAs requires expression of multiple genes. Guedes-Monteiro RF, et al. Biochim Biophys Acta Mol Cell Res, 2019 May. PMID 30759361
    2. Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. Tamura Y, et al. J Biol Chem, 2012 Dec 21. PMID 23124206, Free PMC Article
    3. Phenotypic plasticity and a new small molecule are involved in a fungal-bacterial interaction. Andrade-Domínguez A, et al. Sci Rep, 2021 Sep 28. PMID 34584120, Free PMC Article
    4. Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Merz S, et al. Genome Biol, 2009. PMID 19751518, Free PMC Article
    5. The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. Osman C, et al. J Cell Biol, 2009 Feb 23. PMID 19221197, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial tRNA 5'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in matrix side of mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gep5p
    NP_013192.1
    • hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; localizes to the matrix side of the inner mitochondrial membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      322297..323178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181978.1 → NP_013192.1  TPA: Gep5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LT59, C7GQR4, C8ZD61, D6VY91, Q12393
      UniProtKB/TrEMBL
      G2WIT3, N1NZ75
      Conserved Domains (1) summary
      pfam17053
      Location:9 → 249
      GEP5; Genetic interactor of prohibitin 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12393.1

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