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    NPC2 sterol transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851514, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NPC2
    Official Full Name
    sterol transporter
    Primary source
    SGD:S000002204
    Locus tag
    YDL046W
    See related
    AllianceGenome:SGD:S000002204; FungiDB:YDL046W; VEuPathDB:YDL046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phospholipid binding activity and sterol binding activity. Involved in intracellular sterol transport. Located in fungal-type vacuole lumen. Used to study Niemann-Pick disease and Niemann-Pick disease type C2. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See NPC2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (371240..371761)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Stp4p Neighboring gene type 2A-related serine/threonine-protein phosphatase SIT4 Neighboring gene mitochondrial 37S ribosomal protein YmS-T Neighboring gene FMN adenylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2. Berger AC, et al. Eukaryot Cell, 2005 Nov. PMID 16278452, Free PMC Article
    2. Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein. Moesgaard L, et al. Biochemistry, 2020 Nov 17. PMID 33141558
    3. Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole. Tsuji T, et al. Elife, 2017 Jun 7. PMID 28590904, Free PMC Article
    4. Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins. Winkler MBL, et al. Cell, 2019 Oct 3. PMID 31543266
    5. A quantitative yeast aging proteomics analysis reveals novel aging regulators. Sun Y, et al. Geroscience, 2021 Oct. PMID 34241809, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein.
      Title: Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein.
    2. this study presents four structures of yeast NCR1 and NPC2.
      Title: Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
    3. These data show that Ncr1p and Npc2p proteins promote microautophagy in stationary phase and under nitrogen starvation conditions, likely by increasing sterol in the limiting membrane of the vacuole.
      Title: Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole.
    4. Data show that Npc2p is evolutionarily related to the mammalian NPC2 family of proteins, and is treated similarly to human NPC2 when expressed in mammalian cells.
      Title: Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular sterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular sterol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol transporter
    NP_010237.1
    • Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general 'lipid solubilizer', binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      371240..371761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180105.1 → NP_010237.1  TPA: sterol transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRU9, Q12408
      UniProtKB/TrEMBL
      A6ZXS8, G2WCB4, N1P5V1
      Conserved Domains (1) summary
      cd00917
      Location:44 → 168
      PG-PI_TP; The phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP) has been shown to bind phosphatidylglycerol and phosphatidylinositol, but the biological significance of this is still obscure. These proteins belong to the ML domain family.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12408.1

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